1-hydroxy-19,30-dimethoxy-12-[2-(3-methoxy-4-oxo-cyclohexyl)-1-methyl-ethyl]-15,17,21,23,29,35-hexamethyl-18-triethylsilanyloxy-11,36-dioxa-4-aza-tricyclo[30.3.1.0^4,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone

Base Information

• Chemical Name: 1-hydroxy-19,30-dimethoxy-12-[2-(3-methoxy-4-oxo-cyclohexyl)-1-methyl-ethyl]-15,17,21,23,29,35-hexamethyl-18-triethylsilanyloxy-11,36-dioxa-4-aza-tricyclo[30.3.1.0^4,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone
• CAS No.: 179076-05-2
• Molecular Formula: C₅₇H₉₁NO₁₃Si
• Molecular Weight: 1026.43

Synonyms:1-hydroxy-19,30-dimethoxy-12-[2-(3-methoxy-4-oxo-cyclohexyl)-1-methyl-ethyl]-15,17,21,23,29,35-hexamethyl-18-triethylsilanyloxy-11,36-dioxa-4-aza-tricyclo[30.3.1.0^4,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone

Chemical Property of 1-hydroxy-19,30-dimethoxy-12-[2-(3-methoxy-4-oxo-cyclohexyl)-1-methyl-ethyl]-15,17,21,23,29,35-hexamethyl-18-triethylsilanyloxy-11,36-dioxa-4-aza-tricyclo[30.3.1.0^4,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-hydroxy-19,30-dimethoxy-12-[2-(3-methoxy-4-oxo-cyclohexyl)-1-methyl-ethyl]-15,17,21,23,29,35-hexamethyl-18-triethylsilanyloxy-11,36-dioxa-4-aza-tricyclo[30.3.1.0^4,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone

There total 4 articles about 1-hydroxy-19,30-dimethoxy-12-[2-(3-methoxy-4-oxo-cyclohexyl)-1-methyl-ethyl]-15,17,21,23,29,35-hexamethyl-18-triethylsilanyloxy-11,36-dioxa-4-aza-tricyclo[30.3.1.0^4,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

31-(triethylsilylether)rapamycin (179076-04-1) → 1-hydroxy-19,30-dimethoxy-12-[2-(3-methoxy-4-oxo-cyclohexyl)-1-methyl-ethyl]-15,17,21,23,29,35-hexamethyl-18-triethylsilanyloxy-11,36-dioxa-4-aza-tricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone (179076-05-2)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; at -78 ℃; for 1h;

DOI:10.1016/S0960-894X(99)00007-4

Reference yield:

triethylsilyl chloride (994-30-9) → 1-hydroxy-19,30-dimethoxy-12-[2-(3-methoxy-4-oxo-cyclohexyl)-1-methyl-ethyl]-15,17,21,23,29,35-hexamethyl-18-triethylsilanyloxy-11,36-dioxa-4-aza-tricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone (179076-05-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / imidazole / 1.5 h / 0 °C

2: 96 percent / AcOH, THF, H₂O / 1 h / Ambient temperature

3: 77 percent / (COCl)2, DMSO / 1 h / -78 °C

With tetrahydrofuran; 1H-imidazole; oxalyl dichloride; water; acetic acid; dimethyl sulfoxide;

DOI:10.1016/S0960-894X(99)00007-4

Reference yield:

sirolimus (53123-88-9) → 1-hydroxy-19,30-dimethoxy-12-[2-(3-methoxy-4-oxo-cyclohexyl)-1-methyl-ethyl]-15,17,21,23,29,35-hexamethyl-18-triethylsilanyloxy-11,36-dioxa-4-aza-tricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone (179076-05-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / imidazole / 1.5 h / 0 °C

2: 96 percent / AcOH, THF, H₂O / 1 h / Ambient temperature

3: 77 percent / (COCl)2, DMSO / 1 h / -78 °C

With tetrahydrofuran; 1H-imidazole; oxalyl dichloride; water; acetic acid; dimethyl sulfoxide;

DOI:10.1016/S0960-894X(99)00007-4

upstream raw materials:

31-(triethylsilylether)rapamycin

triethylsilyl chloride

sirolimus

31,42-bis(triethylsilylether)rapamycin

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 179076-05-2 1-hydroxy-19,30-dimethoxy-12-[2-(3-methoxy-4-oxo-cyclohexyl)-1-methyl-ethyl]-15,17,21,23,29,35-hexamethyl-18-triethylsilanyloxy-11,36-dioxa-4-aza-tricyclo[30.3.1.0^4,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone

Send

Send

Metric Ton KG G Pound L ML

Send

Send