5-{4-Amino-1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-5-yl}-2,3-dimethyl-[1,4]benzoquinone

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Chemical Name:5-{4-Amino-1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-5-yl}-2,3-dimethyl-[1,4]benzoquinone
CAS No.:151416-76-1
Molecular Formula:C₂₉H₄₇N₃O₆Si₂
Molecular Weight:589.88
Hs Code.:

5-{4-Amino-1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-5-yl}-2,3-dimethyl-[1,4]benzoquinone

Synonyms:5-{4-Amino-1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-5-yl}-2,3-dimethyl-[1,4]benzoquinone

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Chemical Property of 5-{4-Amino-1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-5-yl}-2,3-dimethyl-[1,4]benzoquinone

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Technology Process of 5-{4-Amino-1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-5-yl}-2,3-dimethyl-[1,4]benzoquinone

There total 4 articles about 5-{4-Amino-1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-5-yl}-2,3-dimethyl-[1,4]benzoquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 151416-81-8
4-Amino-1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-(2,5-dimethoxy-3,4-dimethyl-phenyl)-1H-pyrimidin-2-one

: 151416-76-1
5-{4-Amino-1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-5-yl}-2,3-dimethyl-[1,4]benzoquinone

Guidance literature:: With ammonium cerium(IV) nitrate; In water; acetonitrile;
DOI:10.1021/ja00075a091

Reference yield:

: 39021-83-5
3,6-dimethoxy-o-xylene

: 151416-76-1
5-{4-Amino-1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-5-yl}-2,3-dimethyl-[1,4]benzoquinone

Guidance literature:: Multi-step reaction with 4 steps

1: 1,) HMDS, pyridine, 3.) acid

2: imidazole / dimethylformamide

3: 1.) 1,2,4-triazole, ClPhOPOCl₂, pyridine, 2.) NH₄OH, 3.) NH₃

4: 74 percent / CAN / acetonitrile; H₂O

With pyridine; 1H-imidazole; 1,2,4-Triazole; ammonium hydroxide; ammonium cerium(IV) nitrate; ClPhOPOCl₂; 1,1,1,3,3,3-hexamethyl-disilazane; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00075a091

Reference yield:

: 54-42-2,162239-35-2
5-Iodo-2'-deoxyuridine

: 151416-76-1
5-{4-Amino-1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-5-yl}-2,3-dimethyl-[1,4]benzoquinone

Guidance literature:: Multi-step reaction with 4 steps

1: 1,) HMDS, pyridine, 3.) acid

2: imidazole / dimethylformamide

3: 1.) 1,2,4-triazole, ClPhOPOCl₂, pyridine, 2.) NH₄OH, 3.) NH₃

4: 74 percent / CAN / acetonitrile; H₂O

With pyridine; 1H-imidazole; 1,2,4-Triazole; ammonium hydroxide; ammonium cerium(IV) nitrate; ClPhOPOCl₂; 1,1,1,3,3,3-hexamethyl-disilazane; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00075a091