tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate

Base Information

Chemical Name:tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate
CAS No.:1360911-53-0
Molecular Formula:C₂₀H₂₆N₂O₆
Molecular Weight:390.436
Hs Code.:

Synonyms:tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate

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Chemical Property of tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate

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Technology Process of tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate

There total 1 articles about tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 619-42-1
4-methoxycarbonylphenyl bromide

: 169206-55-7
2-oxo-1-oxa-3,8-diazaspiro<4.5>decane-8-carboxylic acid tert-butyl ester

: 1360911-53-0
tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate

Guidance literature:: With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; for 18h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.8b00306

Reference yield: 98.0%

: 1360911-53-0
tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate

: 1360911-54-1
methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1021/acsmedchemlett.8b00306

Reference yield:

: 1360911-53-0
tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate

: 1360913-91-2
4-(2-oxo-8-((2',3',4'-trifluoro-5-methyl-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methyl)-1-oxa-3,8-diazaspiro[4.5]decan-3-yl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 20 °C

3.1: lithium hydroxide monohydrate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 120 °C / Microwave irradiation

With hydrogenchloride; lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; N,N-dimethyl-formamide;