methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride

Base Information

• Chemical Name: methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride
• CAS No.: 1360911-54-1
• Molecular Formula: C₁₅H₁₈N₂O₄*ClH
• Molecular Weight: 326.78
• Mol file: 1360911-54-1.mol

Synonyms:methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride

Chemical Property of methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride

There total 3 articles about methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate (1360911-53-0) → methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride (1360911-54-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

DOI:10.1021/acsmedchemlett.8b00306

Reference yield:

4-methoxycarbonylphenyl bromide (619-42-1) → methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride (1360911-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / 18 h / Inert atmosphere; Heating

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; caesium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane;

Reference yield:

2-oxo-1-oxa-3,8-diazaspiro<4.5>decane-8-carboxylic acid tert-butyl ester (169206-55-7) → methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride (1360911-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / 18 h / Inert atmosphere; Heating

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; caesium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane;

upstream raw materials:

4-methoxycarbonylphenyl bromide

tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate

2-oxo-1-oxa-3,8-diazaspiro<4.5>decane-8-carboxylic acid tert-butyl ester

Downstream raw materials:

methyl 4-{8-[3-bromo-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoate

methyl 4-(8-(2-bromo-4-methyl-5-(trifluoromethyl)benzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl)benzoate

4-(2-oxo-8-((2',3',4'-trifluoro-5-methyl-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methyl)-1-oxa-3,8-diazaspiro[4.5]decan-3-yl)benzoic acid

methyl 4-[8-(3-bromo-4,5-dichlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoate