Rimonabant hydrochloride

Base Information

Chemical Name:Rimonabant hydrochloride
CAS No.:158681-13-1
Molecular Formula:C22H21Cl3N4O^.HCl
Molecular Weight:500.255
Hs Code.:
European Community (EC) Number:806-144-8
UNII:HL0V2LQZ09
DSSTox Substance ID:DTXSID20166495
Wikidata:Q27279980
Pharos Ligand ID:6DPN7BGNLNKX
ChEMBL ID:CHEMBL558598
Mol file:158681-13-1.mol

Synonyms:acomplia;N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride;rimonabant;Rimonabant Hydrochloride;SR 141716;SR 141716A;SR-141716A;SR141716;SR141716A;Zimulti

Suppliers and Price of Rimonabant hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
SR 141716A
10mg
$ 353.00

TRC
Rimonabant hydrochloride
50mg
$ 360.00

Tocris
SR141716A ≥99%(HPLC)
50
$ 487.00

Tocris
SR141716A ≥99%(HPLC)
10
$ 116.00

Sigma-Aldrich
Rimonabant hydrochloride ≥98% (HPLC)
5mg
$ 74.90

Sigma-Aldrich
Rimonabant hydrochloride ≥98% (HPLC)
25mg
$ 303.00

Medical Isotopes, Inc.
Rimonabant-d10HCl
10 mg
$ 2120.00

Medical Isotopes, Inc.
Rimonabant-d10HCl
1 mg
$ 640.00

DC Chemicals
Rimonabant hydrochloride >98%
1 g
$ 600.00

DC Chemicals
Rimonabant hydrochloride >98%
250 mg
$ 300.00

Total 118 raw suppliers

Chemical Property of Rimonabant hydrochloride

Chemical Property:

Appearance/Colour:White to Off-White Crystalline Solid
Melting Point:230-240 °C
Boiling Point:627.6 °C at 760 mmHg
Flash Point:333.3 °C
PSA：50.16000
LogP:7.06940
Storage Temp.:-20°C Freezer
Solubility.:DMSO: soluble20mg/mL, clear
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:500.051822
Heavy Atom Count:31
Complexity:583

Purity/Quality:

99%, ^*data from raw suppliers

SR 141716A ^*data from reagent suppliers

Safty Information:

Pictogram(s): T,Xi
Hazard Codes:T,Xi
Statements: 25-36
Safety Statements: 26-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)Cl.Cl
Uses The first of a new class of selective (Cannabinoid-1 (CB-1) receptor antagonists A brain cannabinoid receptor (CB1) antagonist. Antiobesity agent. Rimonabant hydrochloride has been used as an antagonist of cannabinoid 1 (CB1) receptor:to study its effects on protein synthesis in C2C12 myotubesto analyze its effects on human astrogliain combination with methanandamide (mAEA) to study its effects on murine gastric vagal afferent mechanosensitivity

Technology Process of Rimonabant hydrochloride

There total 12 articles about Rimonabant hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.7%

: 63234-70-8
N-aminopiperidine hydrochloride

: 162758-35-2
rimonabant acid

: 168273-06-1
rimonabant

: 158681-13-1
rimonabant hydrochloride

Guidance literature:: rimonabant acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 6h;

N-aminopiperidine hydrochloride; With triethylamine; In tetrahydrofuran; at 60 ℃; for 1.5h;

rimonabant; With hydrogenchloride;

Reference yield:

: 2213-43-6
1-Aminopiperidine

: 168273-05-0
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbonyl chloride

: 158681-13-1
rimonabant hydrochloride

Guidance literature:: 1-Aminopiperidine; 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbonyl chloride; With sodium hydroxide; tetrabutylammomium bromide; In dichloromethane; water; at 10 - 25 ℃; for 2 - 3.5h;

With hydrogenchloride; In water; acetone; at 20 - 25 ℃; for 0.5h;