1-(2-chloro-benzyl)-5-fluoro-3-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-ylideneamine

Base Information

Chemical Name:1-(2-chloro-benzyl)-5-fluoro-3-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-ylideneamine
CAS No.:1352721-40-4
Molecular Formula:C₁₉H₂₀ClFN₄
Molecular Weight:358.846
Hs Code.:

Synonyms:1-(2-chloro-benzyl)-5-fluoro-3-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-ylideneamine

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Chemical Property of 1-(2-chloro-benzyl)-5-fluoro-3-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-ylideneamine

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Technology Process of 1-(2-chloro-benzyl)-5-fluoro-3-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-ylideneamine

There total 3 articles about 1-(2-chloro-benzyl)-5-fluoro-3-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-ylideneamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1352721-41-5
4-[3-(2-chloro-benzyl)-6-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-yl]-piperidine-1-carboxylic acid tert-butyl ester

: 1352721-40-4
1-(2-chloro-benzyl)-5-fluoro-3-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-ylideneamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 1h;

Reference yield:

: 611-17-6
1-bromomethyl-2-chlorobenzene

: 1352721-40-4
1-(2-chloro-benzyl)-5-fluoro-3-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-ylideneamine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium iodide / acetonitrile / 0.5 h / 20 °C

2: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

With trifluoroacetic acid; potassium iodide; In dichloromethane; water; acetonitrile;

Reference yield:

: 1352721-39-1
4-(2-amino-6-fluoro-benzoimidazol-1-yl)-piperidine-1-carboxylic acid

: 1352721-40-4
1-(2-chloro-benzyl)-5-fluoro-3-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-ylideneamine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium iodide / acetonitrile / 0.5 h / 20 °C

2: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

With trifluoroacetic acid; potassium iodide; In dichloromethane; water; acetonitrile;