N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide

Base Information

Chemical Name:N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide
CAS No.:1353968-27-0
Molecular Formula:C₂₄H₁₆FN₅O
Molecular Weight:409.422
Hs Code.:

Synonyms:N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide

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Chemical Property of N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide

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Technology Process of N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide

There total 4 articles about N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353967-37-9
5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine

: 108-24-7
acetic anhydride

: 1353968-27-0
N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide

Guidance literature:: 5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-ylamine; acetic anhydride; With acetic acid; at 80 ℃; for 18h;

With ammonia; In water;

Reference yield:

: 80935-78-0
1-chloro-[2,6]naphthyridine

: 1353968-27-0
N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium bis(monoperoxyphthalate)hexahydrate / isopropyl alcohol / 40 h / 20 °C

2.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

3.1: methanesulfonyl chloride; pyridine / 16 h / 0 - 20 °C

3.2: 16 h / 20 °C

4.1: acetic acid / 18 h / 80 °C

With pyridine; magnesium bis(monoperoxyphthalate)hexahydrate; sodium hydrogencarbonate; acetic acid; methanesulfonyl chloride; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1353969-98-8
1-chloro-[2,6]naphthyridine 6-oxide

: 1353968-27-0
N-{5-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[2,6]naphthyridin-1-yl}-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

2.1: methanesulfonyl chloride; pyridine / 16 h / 0 - 20 °C

2.2: 16 h / 20 °C

3.1: acetic acid / 18 h / 80 °C

With pyridine; sodium hydrogencarbonate; acetic acid; methanesulfonyl chloride; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide;