dimethyl N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamate

Base Information

• Chemical Name: dimethyl N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamate
• CAS No.: 118869-56-0
• Molecular Formula: C₂₀H₂₂N₆O₅
• Molecular Weight: 426.432
• Mol file: 118869-56-0.mol

Synonyms:dimethyl N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamate

Chemical Property of dimethyl N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamate

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamate

There total 2 articles about dimethyl N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

dimethyl N-(4-amino-benzoyl)-L-glutamate (52407-60-0) + 2-Amino-5-chloromethylpyrazine-3-carbonitrile (40127-91-1) → dimethyl N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamate (118869-56-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 18h;

DOI:10.1021/jm00105a036

Reference yield: 52.0%

dimethyl N-(4-amino-benzoyl)-L-glutamate (52407-60-0) + 2-Amino-5-chloromethylpyrazine-3-carbonitrile (40127-91-1) → dimethyl N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamate (118869-56-0) + (S)-2-{4-[Bis-(5-amino-6-cyano-pyrazin-2-ylmethyl)-amino]-benzoylamino}-pentanedioic acid di-tert-butyl ester

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00123a001

Reference yield:

dimethyl N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamate (118869-56-0) → N-<4-<<(4-aminopteridin-6-yl)methyl>amino>benzoyl>-L-glutamic acid (118869-51-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Heating

2: 33 percent / Ba(OH)2*8H₂O / aq. ethanol / Ambient temperature; overnight

With barium dihydroxide; In ethanol;

DOI:10.1021/jm00105a036

upstream raw materials:

dimethyl N-(4-amino-benzoyl)-L-glutamate

2-Amino-5-chloromethylpyrazine-3-carbonitrile

Downstream raw materials:

N-<4-<<(4-aminopteridin-6-yl)methyl>amino>benzoyl>-L-glutamic acid