(E)-9-[2-bromo-4-(tert-butyldimethylsilanyloxy)-3-phenyl-but-2-enyl]-adenine

Base Information

Chemical Name:(E)-9-[2-bromo-4-(tert-butyldimethylsilanyloxy)-3-phenyl-but-2-enyl]-adenine
CAS No.:940293-05-0
Molecular Formula:C₂₁H₂₈BrN₅OSi
Molecular Weight:474.476
Hs Code.:

Synonyms:(E)-9-[2-bromo-4-(tert-butyldimethylsilanyloxy)-3-phenyl-but-2-enyl]-adenine

Suppliers and Price of (E)-9-[2-bromo-4-(tert-butyldimethylsilanyloxy)-3-phenyl-but-2-enyl]-adenine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-9-[2-bromo-4-(tert-butyldimethylsilanyloxy)-3-phenyl-but-2-enyl]-adenine

Chemical Property:

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Technology Process of (E)-9-[2-bromo-4-(tert-butyldimethylsilanyloxy)-3-phenyl-but-2-enyl]-adenine

There total 6 articles about (E)-9-[2-bromo-4-(tert-butyldimethylsilanyloxy)-3-phenyl-but-2-enyl]-adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 940292-99-9
(E)-tert-butyl-(3,4-dibromo-2-phenyl-but-2-enyloxy)-dimethylsilane

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 940293-05-0
(E)-9-[2-bromo-4-(tert-butyldimethylsilanyloxy)-3-phenyl-but-2-enyl]-adenine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1080/15257770600793877

Reference yield:

: 736156-58-4
(E)-2-bromo-4-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-but-2-en-1-ol

: 940293-05-0
(E)-9-[2-bromo-4-(tert-butyldimethylsilanyloxy)-3-phenyl-but-2-enyl]-adenine

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / triphenylphosphine; N-bromosuccinimide / CH₂Cl₂ / 4 h / 20 °C

2: 43 percent / NaH / dimethylformamide / 20 °C

With N-Bromosuccinimide; sodium hydride; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/15257770600793877

Reference yield:

: 940292-95-5
(Z)-4-(t-butyldimethylsilyloxy)-3-phenyl-but-2-enoic acid ethyl ester

: 940293-05-0
(E)-9-[2-bromo-4-(tert-butyldimethylsilanyloxy)-3-phenyl-but-2-enyl]-adenine

Guidance literature:: Multi-step reaction with 5 steps

1: 54 percent / Br₂; Et₃N / CCl₄ / 5 h / 0 °C

2: 65 percent / K₂CO₃ / dimethylformamide

3: 96 percent / DIBAL-H / CH₂Cl₂; hexane / 2 h / -20 °C

4: 59 percent / triphenylphosphine; N-bromosuccinimide / CH₂Cl₂ / 4 h / 20 °C

5: 43 percent / NaH / dimethylformamide / 20 °C

With N-Bromosuccinimide; bromine; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triethylamine; triphenylphosphine; In tetrachloromethane; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/15257770600793877