5,7-bis[[4-(trifluoromethyl)phenyl]methyl]-1,3-diazatricyclo[3.3.1.1^3,7]decan-6-one

Base Information

• Chemical Name: 5,7-bis[[4-(trifluoromethyl)phenyl]methyl]-1,3-diazatricyclo[3.3.1.1^3,7]decan-6-one
• CAS No.: 1053242-58-2
• Molecular Formula: C₂₄H₂₂F₆N₂O
• Molecular Weight: 468.442

Synonyms:5,7-bis[[4-(trifluoromethyl)phenyl]methyl]-1,3-diazatricyclo[3.3.1.1^3,7]decan-6-one

Chemical Property of 5,7-bis[[4-(trifluoromethyl)phenyl]methyl]-1,3-diazatricyclo[3.3.1.1^3,7]decan-6-one

Chemical Property:

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Technology Process of 5,7-bis[[4-(trifluoromethyl)phenyl]methyl]-1,3-diazatricyclo[3.3.1.1^3,7]decan-6-one

There total 2 articles about 5,7-bis[[4-(trifluoromethyl)phenyl]methyl]-1,3-diazatricyclo[3.3.1.1^3,7]decan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1,5-bis[4-(trifluoromethyl)phenyl]-3-pentanone (1053242-55-9) + hexamethylenetetramine (100-97-0) → 5,7-bis[[4-(trifluoromethyl)phenyl]methyl]-1,3-diazatricyclo[3.3.1.13,7]decan-6-one (1053242-58-2)

Guidance literature:

With acetic acid; In ethanol; Heating;

DOI:10.1021/jo801423a

Reference yield:

4-(trifluoromethyl)benzylic alcohol (349-95-1) → 5,7-bis[[4-(trifluoromethyl)phenyl]methyl]-1,3-diazatricyclo[3.3.1.13,7]decan-6-one (1053242-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; triphenylphosphine; potassium hydroxide / 100 °C

2: acetic acid / ethanol / 15 h / Reflux

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; acetic acid; triphenylphosphine; potassium hydroxide; In ethanol; 2: |Mannich Aminomethylation;

DOI:10.2174/15734064113099900002

Reference yield: 100.0%

5,7-bis[[4-(trifluoromethyl)phenyl]methyl]-1,3-diazatricyclo[3.3.1.13,7]decan-6-one (1053242-58-2) + Allyl chloroformate (2937-50-0) → 1,5-bis[[4-(trifluoromethyl)phenyl]methyl]-3,7-bis[(2-propenyloxy)carbonyl]-3,7-diazabicyclo[3.3.1]nonan-9-one

Guidance literature:

In chloroform; at 20 ℃; for 120h;

DOI:10.1021/jo801423a

upstream raw materials:

1,5-bis[4-(trifluoromethyl)phenyl]-3-pentanone

hexamethylenetetramine

4-(trifluoromethyl)benzylic alcohol

Downstream raw materials:

5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-1,3-diaza-2-thia-tricyclo[3.3.1.1^3,7]decan-6-one 2-oxide

5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-1,3-diaza-2-thia-tricyclo[3.3.1.1^3,7]decan-6-one 2,2-dioxide

5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-2-chloro-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decane-6-one 2-oxide

sodium 5,7-bis[(4-(trifluoromethyl)phenyl)methyl]-6-oxo-1,3-diaza-2-phospha-tricyclo[3.3.1.1^3,7]decan-2-olate 2-oxide

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