2,6-dimethyl-5-phenyl-1-(2'-hydroxyphenyl)-4-oxo-1,4-dihydropyrimidine

Base Information

• Chemical Name: 2,6-dimethyl-5-phenyl-1-(2'-hydroxyphenyl)-4-oxo-1,4-dihydropyrimidine
• CAS No.: 122664-41-9
• Molecular Formula: C₁₈H₁₆N₂O₂
• Molecular Weight: 292.337
• Mol file: 122664-41-9.mol

Synonyms:2,6-dimethyl-5-phenyl-1-(2'-hydroxyphenyl)-4-oxo-1,4-dihydropyrimidine

Chemical Property of 2,6-dimethyl-5-phenyl-1-(2'-hydroxyphenyl)-4-oxo-1,4-dihydropyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-dimethyl-5-phenyl-1-(2'-hydroxyphenyl)-4-oxo-1,4-dihydropyrimidine

There total 2 articles about 2,6-dimethyl-5-phenyl-1-(2'-hydroxyphenyl)-4-oxo-1,4-dihydropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-acetyl-β-phenylacetoacetamide (122664-30-6) + 2-amino-phenol (95-55-6) → 2,6-dimethyl-5-phenyl-1-(2'-hydroxyphenyl)-4-oxo-1,4-dihydropyrimidine (122664-41-9)

Guidance literature:

In acetic acid; for 1h;

DOI:10.1007/BF00758288

Reference yield:

Benzeneacetamide (103-81-1) → 2,6-dimethyl-5-phenyl-1-(2'-hydroxyphenyl)-4-oxo-1,4-dihydropyrimidine (122664-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / BF₃, AcOH / 48 h

2: 94 percent / AcOH / 1 h / Heating

With boron trifluoride; acetic acid;

DOI:10.1002/jhet.5570360115

Reference yield: 88.0%

2,6-dimethyl-5-phenyl-1-(2'-hydroxyphenyl)-4-oxo-1,4-dihydropyrimidine (122664-41-9) + acetic anhydride (108-24-7) → 2,6-dimethyl-5-phenyl-1-(2'-acetoxyphenyl)-4-oxo-1,4-dihydropyrimidine (122664-44-2)

Guidance literature:

With perchloric acid; Heating;

upstream raw materials:

N-acetyl-β-phenylacetoacetamide

2-amino-phenol

Benzeneacetamide

Downstream raw materials:

2,6-dimethyl-5-phenyl-1-(2'-acetoxyphenyl)-4-oxopyridinium perchlorate

2,6-dimethyl-5-phenyl-1-(2'-acetoxyphenyl)-4-oxo-1,4-dihydropyrimidine

Refernces

• 1、 Vedernikova, I. V.,Ryabukhin, Yu. I.,Haitin, M. I.,Simkina, Yu. N.. "SYNTHESE ET IDENTIFICATION DES 4-OXO-1,4-DIHYDROPYRIMIDINES EN VUE DES APPLICATIONS PHARMACOLOGIQUES". . p. 487 - 492. Retrieved 2007/10/02.