2-Acetamido-2-[2-(4-heptylphenyl)ethyl]-1,3-propanediol

Base Information

Chemical Name:2-Acetamido-2-[2-(4-heptylphenyl)ethyl]-1,3-propanediol
CAS No.:162361-42-4
Molecular Formula:C₂₀H₃₃NO₃
Molecular Weight:335.487
Hs Code.:

Synonyms:2-Acetamido-2-[2-(4-heptylphenyl)ethyl]-1,3-propanediol

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Chemical Property of 2-Acetamido-2-[2-(4-heptylphenyl)ethyl]-1,3-propanediol

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Technology Process of 2-Acetamido-2-[2-(4-heptylphenyl)ethyl]-1,3-propanediol

There total 10 articles about 2-Acetamido-2-[2-(4-heptylphenyl)ethyl]-1,3-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 296282-53-6
2-acetylamino-2-[2-(4-heptyl-phenyl)-ethyl]-malonic acid diethyl ester

: 162361-42-4
2-Acetamido-2-[2-(4-heptylphenyl)ethyl]-1,3-propanediol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm000173z

Reference yield:

: 2528-61-2
Heptanoic acid chloride

: 162361-42-4
2-Acetamido-2-[2-(4-heptylphenyl)ethyl]-1,3-propanediol

Guidance literature:: Multi-step reaction with 7 steps

1.1: AlCl₃ / 1,2-dichloro-ethane / 3 h / 20 °C

2.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C

3.1: NaOMe; MeOH / 2 h / Heating

4.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

5.1: NaI / butan-2-one / 2 h / Heating

6.1: sodium ethoxide / ethanol / 0.5 h / 20 °C

6.2: ethanol / 3 h / 65 °C

7.1: LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

With methanol; triethylsilane; lithium aluminium tetrahydride; aluminium trichloride; sodium methylate; sodium ethanolate; triethylamine; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; butanone; 1.1: Friedel-Crafts acylation / 2.1: Reduction / 3.1: methanolysis / 4.1: mesylation / 5.1: Iodination / 6.1: Metallation / 6.2: Alkylation / 7.1: Reduction;
DOI:10.1021/jm000173z

Reference yield:

: 104947-95-7
4-heptylphenethyl alcohol

: 162361-42-4
2-Acetamido-2-[2-(4-heptylphenyl)ethyl]-1,3-propanediol

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

2.1: NaI / butan-2-one / 2 h / Heating

3.1: sodium ethoxide / ethanol / 0.5 h / 20 °C

3.2: ethanol / 3 h / 65 °C

4.1: LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

With lithium aluminium tetrahydride; sodium ethanolate; triethylamine; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; butanone; 1.1: mesylation / 2.1: Iodination / 3.1: Metallation / 3.2: Alkylation / 4.1: Reduction;
DOI:10.1021/jm000173z