acetic acid 2-acetoxymethyl-2-acetylamino-4-(4-heptyl-phenyl)-butyl ester

Base Information

Chemical Name:acetic acid 2-acetoxymethyl-2-acetylamino-4-(4-heptyl-phenyl)-butyl ester
CAS No.:162361-43-5
Molecular Formula:C₂₄H₃₇NO₅
Molecular Weight:419.561
Hs Code.:

Synonyms:

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Chemical Property of acetic acid 2-acetoxymethyl-2-acetylamino-4-(4-heptyl-phenyl)-butyl ester

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Technology Process of acetic acid 2-acetoxymethyl-2-acetylamino-4-(4-heptyl-phenyl)-butyl ester

There total 10 articles about acetic acid 2-acetoxymethyl-2-acetylamino-4-(4-heptyl-phenyl)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2528-61-2
Heptanoic acid chloride

: 162361-43-5
acetic acid 2-acetoxymethyl-2-acetylamino-4-(4-heptyl-phenyl)-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: AlCl₃ / 1,2-dichloro-ethane / 3 h / 20 °C

2.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C

3.1: NaOMe; MeOH / 2 h / Heating

4.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

5.1: NaI / butan-2-one / 2 h / Heating

6.1: sodium ethoxide / ethanol / 0.5 h / 20 °C

6.2: ethanol / 3 h / 65 °C

7.1: LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

8.1: pyridine / 16 h / 20 °C

With pyridine; methanol; triethylsilane; lithium aluminium tetrahydride; aluminium trichloride; sodium methylate; sodium ethanolate; triethylamine; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; butanone; 1.1: Friedel-Crafts acylation / 2.1: Reduction / 3.1: methanolysis / 4.1: mesylation / 5.1: Iodination / 6.1: Metallation / 6.2: Alkylation / 7.1: Reduction / 8.1: Acetylation;
DOI:10.1021/jm000173z

Reference yield:

: 104947-95-7
4-heptylphenethyl alcohol

: 162361-43-5
acetic acid 2-acetoxymethyl-2-acetylamino-4-(4-heptyl-phenyl)-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

2.1: NaI / butan-2-one / 2 h / Heating

3.1: sodium ethoxide / ethanol / 0.5 h / 20 °C

3.2: ethanol / 3 h / 65 °C

4.1: LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

5.1: pyridine / 16 h / 20 °C

With pyridine; lithium aluminium tetrahydride; sodium ethanolate; triethylamine; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; butanone; 1.1: mesylation / 2.1: Iodination / 3.1: Metallation / 3.2: Alkylation / 4.1: Reduction / 5.1: Acetylation;
DOI:10.1021/jm000173z

Reference yield:

: 103-45-7
acetic acid phenethyl ester

: 162361-43-5
acetic acid 2-acetoxymethyl-2-acetylamino-4-(4-heptyl-phenyl)-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: AlCl₃ / 1,2-dichloro-ethane / 3 h / 20 °C

2.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C

3.1: NaOMe; MeOH / 2 h / Heating

4.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

5.1: NaI / butan-2-one / 2 h / Heating

6.1: sodium ethoxide / ethanol / 0.5 h / 20 °C

6.2: ethanol / 3 h / 65 °C

7.1: LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

8.1: pyridine / 16 h / 20 °C

With pyridine; methanol; triethylsilane; lithium aluminium tetrahydride; aluminium trichloride; sodium methylate; sodium ethanolate; triethylamine; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; butanone; 1.1: Friedel-Crafts acylation / 2.1: Reduction / 3.1: methanolysis / 4.1: mesylation / 5.1: Iodination / 6.1: Metallation / 6.2: Alkylation / 7.1: Reduction / 8.1: Acetylation;
DOI:10.1021/jm000173z