2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (4-fluorophenyl)amide

Base Information

Chemical Name:2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (4-fluorophenyl)amide
CAS No.:677764-50-0
Molecular Formula:C₁₅H₁₅FN₂OS
Molecular Weight:290.361
Hs Code.:

Synonyms:2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (4-fluorophenyl)amide

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Chemical Property of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (4-fluorophenyl)amide

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Technology Process of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (4-fluorophenyl)amide

There total 3 articles about 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (4-fluorophenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₁₅FN₂O

: 677764-50-0
2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (4-fluorophenyl)amide

Guidance literature:: With sulfur; diethylamine; In ethanol; at 45 - 50 ℃;
DOI:10.1016/j.ejmech.2010.05.061

Reference yield:

: 1735-88-2
2-cyano-N-[4-(fluoro)phenyl]acetamide

: 677764-50-0
2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (4-fluorophenyl)amide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium sulfate; acetic acid; ammonium acetate / 1 h / 100 °C

2: sulfur; morpholine / ethanol / 5 h / 90 °C

With morpholine; sulfur; ammonium acetate; acetic acid; sodium sulfate; In ethanol; 1: |Knoevenagel Condensation;
DOI:10.1021/acs.jmedchem.7b00020

Reference yield:

: 371-40-4
4-fluoroaniline

: 677764-50-0
2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid (4-fluorophenyl)amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: sodium sulfate; acetic acid; ammonium acetate / 1 h / 100 °C

3: sulfur; morpholine / ethanol / 5 h / 90 °C

With morpholine; sulfur; ammonium acetate; acetic acid; sodium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; 2: |Knoevenagel Condensation;
DOI:10.1021/acs.jmedchem.7b00020