4-[4-(triflluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine

Base Information

• Chemical Name: 4-[4-(triflluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine
• CAS No.: 1595282-82-8
• Molecular Formula: C₁₃H₈F₃N₃
• Molecular Weight: 263.222
• Mol file: 1595282-82-8.mol

Synonyms:4-[4-(triflluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property of 4-[4-(triflluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 4-[4-(triflluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine

There total 1 articles about 4-[4-(triflluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-trifluoromethylphenylboronic acid (128796-39-4) + 4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → 4-[4-(triflluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine (1595282-82-8)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bmc.2014.02.024

Reference yield: 71.0%

5-bromo-2-thiophencarboxaldehyde (4701-17-1) + 4-[4-(triflluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine (1595282-82-8) → 5-(4-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)thiophene-2-carbaldehyde (1595282-85-1)

Guidance literature:

With potassium phosphate; copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bmc.2014.02.024

Reference yield: 69.0%

m-iodobenzaldehyde (696-41-3) + 4-[4-(triflluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine (1595282-82-8) → 3-(4-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzaldehyde (1595282-83-9)

Guidance literature:

With potassium phosphate; copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bmc.2014.02.024

upstream raw materials:

4-trifluoromethylphenylboronic acid

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Downstream raw materials:

3-(3-(4-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzylamino)benzoic acid

3-((3-(4-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenylamino)methyl)benzoic acid

3-((5-(4-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)thiophen-2-yl)methylamino)benzoic acid

3-(4-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzenamine