3-(4-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzenamine

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Chemical Name:3-(4-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzenamine
CAS No.:1595282-84-0
Molecular Formula:C₁₉H₁₃F₃N₄
Molecular Weight:354.334
Hs Code.:

Synonyms:3-(4-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzenamine

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Chemical Property of 3-(4-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzenamine

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Technology Process of 3-(4-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzenamine

There total 3 articles about 3-(4-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1595282-82-8
4-[4-(triflluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine

: 626-01-7
3-Iodoaniline

: 1595282-84-0
3-(4-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzenamine

Guidance literature:: With potassium phosphate; copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.02.024

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1595282-84-0
3-(4-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzenamine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 24 h / 100 °C / Inert atmosphere

2: copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; potassium phosphate / 1,4-dioxane / 24 h / 100 °C / Inert atmosphere

With potassium phosphate; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine; In 1,4-dioxane; water; 1: |Suzuki Coupling / 2: |Buchwald Indole Synthesis;
DOI:10.1016/j.bmc.2014.02.024

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1595282-84-0
3-(4-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzenamine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 24 h / 100 °C / Inert atmosphere

2: copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; potassium phosphate / 1,4-dioxane / 24 h / 100 °C / Inert atmosphere

With potassium phosphate; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine; In 1,4-dioxane; water; 1: |Suzuki Coupling / 2: |Buchwald Indole Synthesis;
DOI:10.1016/j.bmc.2014.02.024