(2S,8S)-2-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-1-(toluene-4-sulfonyl)-8-(2-triethylsilanyloxy-ethyl)-1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Base Information

Chemical Name:(2S,8S)-2-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-1-(toluene-4-sulfonyl)-8-(2-triethylsilanyloxy-ethyl)-1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
CAS No.:173472-41-8
Molecular Formula:C₄₁H₆₁N₃O₄SSi₂
Molecular Weight:748.19
Hs Code.:

(2S,8S)-2-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-1-(toluene-4-sulfonyl)-8-(2-triethylsilanyloxy-ethyl)-1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Synonyms:(2S,8S)-2-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-1-(toluene-4-sulfonyl)-8-(2-triethylsilanyloxy-ethyl)-1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

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Chemical Property of (2S,8S)-2-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-1-(toluene-4-sulfonyl)-8-(2-triethylsilanyloxy-ethyl)-1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

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Technology Process of (2S,8S)-2-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-1-(toluene-4-sulfonyl)-8-(2-triethylsilanyloxy-ethyl)-1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

There total 15 articles about (2S,8S)-2-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-1-(toluene-4-sulfonyl)-8-(2-triethylsilanyloxy-ethyl)-1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 173472-41-8
(2S,8S)-2-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-1-(toluene-4-sulfonyl)-8-(2-triethylsilanyloxy-ethyl)-1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

2: 81 percent / acetonitrile / 50 h / Heating

3: 87 percent / NaH / paraffin; tetrahydrofuran / Ambient temperature

4: 100 percent / methanol; CH₂Cl₂ / 1 h / Ambient temperature

5: 65 percent / LiAlH₄ / 1,2-dimethoxy-ethane / 0.75 h / Ambient temperature

6: 79 percent / imidazole / acetonitrile / 2 h / Ambient temperature

7: 84 percent / acetonitrile / 35 °C

8: 1.) EtNiPr₂, MeOTf, 2.) EtNiPr₂ / 1.) CH₂Cl₂, 0 deg C, 2.5 h, 2.) reflux, overnight

With 1H-imidazole; lithium aluminium tetrahydride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; methyl trifluoromethanesulfonate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; acetonitrile; paraffin;

Reference yield:

: 173472-40-7
N-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-1-(2-{3-[(R)-1-(2-methylsulfanyl-ethyl)-3-triethylsilanyloxy-propyl]-thioureido}-ethyl)-butyl]-4-methyl-benzenesulfonamide

: 173472-41-8
(2S,8S)-2-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-1-(toluene-4-sulfonyl)-8-(2-triethylsilanyloxy-ethyl)-1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; methyl trifluoromethanesulfonate; In dichloromethane;
DOI:10.1016/0957-4166(95)00354-R

Reference yield:

: 51693-17-5
(S)-toluene-4-sulfonic acid 5-oxo-pyrrolidin-2-ylmethyl ester

: 173472-41-8
(2S,8S)-2-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-1-(toluene-4-sulfonyl)-8-(2-triethylsilanyloxy-ethyl)-1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / acetonitrile / 50 h / Heating

2: 87 percent / NaH / paraffin; tetrahydrofuran / Ambient temperature

3: 100 percent / methanol; CH₂Cl₂ / 1 h / Ambient temperature

4: 65 percent / LiAlH₄ / 1,2-dimethoxy-ethane / 0.75 h / Ambient temperature

5: 79 percent / imidazole / acetonitrile / 2 h / Ambient temperature

6: 84 percent / acetonitrile / 35 °C

7: 1.) EtNiPr₂, MeOTf, 2.) EtNiPr₂ / 1.) CH₂Cl₂, 0 deg C, 2.5 h, 2.) reflux, overnight

With 1H-imidazole; lithium aluminium tetrahydride; sodium hydride; N-ethyl-N,N-diisopropylamine; methyl trifluoromethanesulfonate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; acetonitrile; paraffin;