tert-butyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-methyl-1H-indole-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-methyl-1H-indole-1-carboxylate
CAS No.:1393131-15-1
Molecular Formula:C₂₉H₂₇NO₄
Molecular Weight:453.538
Hs Code.:

Synonyms:tert-butyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-methyl-1H-indole-1-carboxylate

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Chemical Property of tert-butyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-methyl-1H-indole-1-carboxylate

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Technology Process of tert-butyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-methyl-1H-indole-1-carboxylate

There total 5 articles about tert-butyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-methyl-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1393130-99-8
tert-butyl acetyl(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)carbamate

: 98-88-4
benzoyl chloride

: 1393131-15-1
tert-butyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-methyl-1H-indole-1-carboxylate

Guidance literature:: With tributylphosphine; triethylamine; In dichloromethane; at 20 ℃; for 3h; chemoselective reaction; Inert atmosphere;
DOI:10.1039/c2cc33972b

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1393131-15-1
tert-butyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-methyl-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C / Inert atmosphere

3: toluene / 12 h / 80 °C / Inert atmosphere

4: dmap; triethylamine / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

5: tributylphosphine; triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With dmap; tributylphosphine; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; toluene; 5: Wittig reaction;
DOI:10.1039/c2cc33972b

Reference yield:

: 5344-90-1
2-Aminobenzyl alcohol

: 1393131-15-1
tert-butyl 3-((Z)-2-(benzoyloxy)-2-phenylvinyl)-2-methyl-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C / Inert atmosphere

3: toluene / 12 h / 80 °C / Inert atmosphere

4: dmap; triethylamine / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

5: tributylphosphine; triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With dmap; tributylphosphine; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; toluene; 5: Wittig reaction;
DOI:10.1039/c2cc33972b