2-(4-(5-(1-(((ethylcarbamoyl)(phenethyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoic acid

Base Information

Chemical Name:2-(4-(5-(1-(((ethylcarbamoyl)(phenethyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoic acid
CAS No.:1621514-01-9
Molecular Formula:C₂₈H₃₃N₃O₇
Molecular Weight:523.586
Hs Code.:

Synonyms:2-(4-(5-(1-(((ethylcarbamoyl)(phenethyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoic acid

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Chemical Property of 2-(4-(5-(1-(((ethylcarbamoyl)(phenethyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoic acid

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Technology Process of 2-(4-(5-(1-(((ethylcarbamoyl)(phenethyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoic acid

There total 6 articles about 2-(4-(5-(1-(((ethylcarbamoyl)(phenethyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1621513-96-9
2-methyl-2-(4-(5-(1-((phenethylcarbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoic acid

: 109-90-0
ethyl isocyanate

: 1621514-01-9
2-(4-(5-(1-(((ethylcarbamoyl)(phenethyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoic acid

Guidance literature:: With triethylamine; copper(l) chloride; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/anie.201310618

Reference yield:

: 343322-79-2
tert-butyl 2-(4-formylphenoxy)-2-methylpropanoate

: 1621514-01-9
2-(4-(5-(1-(((ethylcarbamoyl)(phenethyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 12 h / 65 °C / Inert atmosphere

2: N-chloro-succinimide; pyridine; triethylamine / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere

3: pyridine; copper(l) chloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 6 h / 20 °C / Inert atmosphere

5: triethylamine; copper(l) chloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

With pyridine; N-chloro-succinimide; hydroxylamine hydrochloride; sodium carbonate; triethylamine; trifluoroacetic acid; copper(l) chloride; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1002/anie.201310618

Reference yield:

: 1621513-91-4
tert-butyl 2-(4-((hydroxyimino)methyl)phenoxy)-2-methylpropanoate

: 1621514-01-9
2-(4-(5-(1-(((ethylcarbamoyl)(phenethyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-chloro-succinimide; pyridine; triethylamine / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere

2: pyridine; copper(l) chloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 6 h / 20 °C / Inert atmosphere

4: triethylamine; copper(l) chloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

With pyridine; N-chloro-succinimide; triethylamine; trifluoroacetic acid; copper(l) chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201310618