2-methyl-2-(4-(5-(1-((phenethylcarbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoic acid

Base Information

Chemical Name:2-methyl-2-(4-(5-(1-((phenethylcarbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoic acid
CAS No.:1621513-96-9
Molecular Formula:C₂₅H₂₈N₂O₆
Molecular Weight:452.507
Hs Code.:

Synonyms:2-methyl-2-(4-(5-(1-((phenethylcarbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoic acid

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Chemical Property of 2-methyl-2-(4-(5-(1-((phenethylcarbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoic acid

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Technology Process of 2-methyl-2-(4-(5-(1-((phenethylcarbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoic acid

There total 5 articles about 2-methyl-2-(4-(5-(1-((phenethylcarbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1621513-94-7
tert-butyl 2-methyl-2-(4-(5-(1-((phenethylcarbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoate

: 1621513-96-9
2-methyl-2-(4-(5-(1-((phenethylcarbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1002/anie.201310618

Reference yield:

: 343322-79-2
tert-butyl 2-(4-formylphenoxy)-2-methylpropanoate

: 1621513-96-9
2-methyl-2-(4-(5-(1-((phenethylcarbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 12 h / 65 °C / Inert atmosphere

2: N-chloro-succinimide; pyridine; triethylamine / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere

3: pyridine; copper(l) chloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 6 h / 20 °C / Inert atmosphere

With pyridine; N-chloro-succinimide; hydroxylamine hydrochloride; sodium carbonate; triethylamine; trifluoroacetic acid; copper(l) chloride; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1002/anie.201310618

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1621513-96-9
2-methyl-2-(4-(5-(1-((phenethylcarbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; magnesium sulfate / N,N-dimethyl-formamide / Inert atmosphere

2: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 12 h / 65 °C / Inert atmosphere

3: N-chloro-succinimide; pyridine; triethylamine / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere

4: pyridine; copper(l) chloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 6 h / 20 °C / Inert atmosphere

With pyridine; N-chloro-succinimide; hydroxylamine hydrochloride; sodium carbonate; magnesium sulfate; potassium carbonate; triethylamine; trifluoroacetic acid; copper(l) chloride; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/anie.201310618