3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]-2,6-difluorobenzaldehyde

Base Information

Chemical Name:3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]-2,6-difluorobenzaldehyde
CAS No.:1278652-53-1
Molecular Formula:C₂₀H₁₁ClF₂N₂O
Molecular Weight:368.77
Hs Code.:

Synonyms:3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]-2,6-difluorobenzaldehyde

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Chemical Property of 3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]-2,6-difluorobenzaldehyde

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Technology Process of 3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]-2,6-difluorobenzaldehyde

There total 4 articles about 3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]-2,6-difluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 870718-06-2
(2,4-difluoro-3-formylphenyl)boronic acid

: 1278250-11-5
5-bromo-2-(4-chlorophenyl)pyrazolo[1,5-a]pyridine

: 1278652-53-1
3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]-2,6-difluorobenzaldehyde

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In tetrahydrofuran; water; at 60 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1278250-09-1
2-(4-bromopyridin-2-yl)-1-(4-chlorophenyl)ethanone

: 1278652-53-1
3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]-2,6-difluorobenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: mesitylenesulfonylhydroxylamine / dichloromethane / 30 h / 0 - 20 °C

2: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 2 h / 60 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; mesitylenesulfonylhydroxylamine; caesium carbonate; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 22282-99-1
4-bromo-2-methylpyridine

: 1278652-53-1
3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]-2,6-difluorobenzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 5 - 20 °C / Inert atmosphere

2: mesitylenesulfonylhydroxylamine / dichloromethane / 30 h / 0 - 20 °C

3: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 2 h / 60 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; mesitylenesulfonylhydroxylamine; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water;