(S)-benzyl 1-(6-fluoro-3-(5-fluoropyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)ethylcarbamate

Base Information

Chemical Name:(S)-benzyl 1-(6-fluoro-3-(5-fluoropyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)ethylcarbamate
CAS No.:1338484-00-6
Molecular Formula:C₂₂H₁₈F₂N₄O₂
Molecular Weight:408.407
Hs Code.:

Synonyms:(S)-benzyl 1-(6-fluoro-3-(5-fluoropyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)ethylcarbamate

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Chemical Property of (S)-benzyl 1-(6-fluoro-3-(5-fluoropyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)ethylcarbamate

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Technology Process of (S)-benzyl 1-(6-fluoro-3-(5-fluoropyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)ethylcarbamate

There total 6 articles about (S)-benzyl 1-(6-fluoro-3-(5-fluoropyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 872041-86-6
5-fluoropyridine-3-boronic acid

: 1338484-01-7
(S)-benzyl 1-(6-fluoro-3-iodoimidazo[1,2-a]pyridin-2-yl)ethylcarbamate

: 1338484-00-6
(S)-benzyl 1-(6-fluoro-3-(5-fluoropyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)ethylcarbamate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; acetonitrile; at 100 ℃; for 2h;
DOI:10.1021/acs.jmedchem.5b01651

Reference yield:

: 1338484-01-7
(S)-benzyl 1-(6-fluoro-3-iodoimidazo[1,2-a]pyridin-2-yl)ethylcarbamate

: 98-80-6
phenylboronic acid

: 1338484-00-6
(S)-benzyl 1-(6-fluoro-3-(5-fluoropyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)ethylcarbamate

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 110 ℃; for 2h; Microwave irradiation;

Reference yield:

: 1142-20-7
N-Cbz-Ala

: 1338484-00-6
(S)-benzyl 1-(6-fluoro-3-(5-fluoropyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 1.5 h / -20 °C

1.2: 1 h / 0 - 20 °C

1.3: 0.5 h

2.1: ethanol / Reflux

3.1: N-iodo-succinimide / acetonitrile / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; acetonitrile / 2 h / 100 °C

With 4-methyl-morpholine; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; isobutyl chloroformate; In tetrahydrofuran; ethanol; water; acetonitrile; 4.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.5b01651