N-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

Base Information

• Chemical Name: N-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide
• CAS No.: 1240501-34-1
• Molecular Formula: C₂₄H₃₁BN₂O₅S
• Molecular Weight: 470.398

Synonyms:N-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

Chemical Property of N-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

Chemical Property:

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Technology Process of N-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

There total 1 articles about N-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-(1,1-dioxo-1lambda* 6 *-thiomorpholin-4-ylmethyl)-phenylamine (263339-24-8) + 4-carboxyphenylboronic acid pinacol ester (180516-87-4) → N-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (1240501-34-1)

Guidance literature:

With NMM; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In acetonitrile;

Reference yield: 73.0%

2-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester (1353498-19-7) + N-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (1240501-34-1) → tert-butyl (2S)-2-[4-[4-[4-[[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]carbamoyl]phenyl]phenyl]imidazol-2-yl]pyrrolidine-1-carboxylate (1240501-32-9)

Guidance literature:

With caesium carbonate; Pd(PPh₃)4; In 1,2-dimethoxyethane; water; acetone;

Reference yield:

tetrakis(triphenylphosphine) palladium(0) (14221-01-3) + tert-butyl (3R)-3-[4-(4-bromophenyl)-1H-imidazol-2-yl]morpholine-4-carboxylate (1240501-37-4) + N-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (1240501-34-1) → tert-butyl (3R)-3-[5-[4-[4-[[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]carbamoyl]phenyl]phenyl]-1H-imidazol-2-yl]morpholine-4-carboxylate (1240501-44-3)

Guidance literature:

caesium carbonate; In 1,2-dimethoxyethane; water;

upstream raw materials:

4-(1,1-dioxo-1lambda* 6 *-thiomorpholin-4-ylmethyl)-phenylamine

4-carboxyphenylboronic acid pinacol ester

Downstream raw materials:

tert-butyl (3R)-3-[5-[4-[4-[[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]carbamoyl]phenyl]phenyl]-1H-imidazol-2-yl]morpholine-4-carboxylate

tert-butyl (2S)-2-[5-[4-[4-[[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]carbamoyl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carboxylate

tert-butyl (2S)-2-[4-[4-[4-[[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]carbamoyl]phenyl]phenyl]imidazol-2-yl]pyrrolidine-1-carboxylate

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