C₂₄H₂₆Cl₂FN₅O

Base Information

Chemical Name:C₂₄H₂₆Cl₂FN₅O
CAS No.:1421270-68-9
Molecular Formula:C₂₄H₂₆Cl₂FN₅O
Molecular Weight:490.408
Hs Code.:

C<sub>24</sub>H<sub>26</sub>Cl<sub>2</sub>FN<sub>5</sub>O

Synonyms:C₂₄H₂₆Cl₂FN₅O

Suppliers and Price of C₂₄H₂₆Cl₂FN₅O

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Crysdot
(R)-5-(1-(7-Azaspiro[3.5]nonan-2-yl)-1H-pyrazol-4-yl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine 97%
100mg
$ 400.00

Alichem
(R)-5-(1-(7-Azaspiro[3.5]nonan-2-yl)-1H-pyrazol-4-yl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
100mg
$ 428.00

Total 1 raw suppliers

Chemical Property of C₂₄H₂₆Cl₂FN₅O

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(R)-5-(1-(7-Azaspiro[3.5]nonan-2-yl)-1H-pyrazol-4-yl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine 97% ^*data from reagent suppliers

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Technology Process of C₂₄H₂₆Cl₂FN₅O

There total 6 articles about C₂₄H₂₆Cl₂FN₅O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1421270-73-6
(R)-tert-butyl 2-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate

: 1421270-68-9
C₂₄H₂₆Cl₂FN₅O

Guidance literature:: (R)-tert-butyl 2-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate; With formic acid; at 20 - 40 ℃; for 1.5h;

With sodium carbonate; In water; ethyl acetate; at 20 ℃; for 0.5h; Sonication;

Reference yield:

: 614729-59-8
2-((methylsulfonyl)oxy)-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

: 1421270-68-9
C₂₄H₂₆Cl₂FN₅O

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.75 h / 0 - 20 °C / Inert atmosphere

1.2: 19 h / 20 - 80 °C

2.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 24 h / 80 °C / Inert atmosphere

3.1: formic acid / 1.5 h / 20 - 40 °C

3.2: 0.5 h / 20 °C / Sonication

With bis-triphenylphosphine-palladium(II) chloride; formic acid; sodium hydride; sodium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 159635-49-1
tert-butyl 4-methylidenepiperidine-1-carboxylate

: 1421270-68-9
C₂₄H₂₆Cl₂FN₅O

Guidance literature:: Multi-step reaction with 6 steps

1.1: zinc/copper couple / 1,2-dimethoxyethane; tert-butyl methyl ether / 15 - 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 26 h / 0 - 20 °C / Cooling with ice

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.75 h / 0 - 20 °C / Inert atmosphere

4.2: 19 h / 20 - 80 °C

5.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 24 h / 80 °C / Inert atmosphere

6.1: formic acid / 1.5 h / 20 - 40 °C

6.2: 0.5 h / 20 °C / Sonication

With dmap; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; formic acid; zinc/copper couple; sodium hydride; sodium carbonate; triethylamine; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide; mineral oil;