(R)-tert-butyl 2-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 2-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate
CAS No.:1421270-73-6
Molecular Formula:C₂₉H₃₄Cl₂FN₅O₃
Molecular Weight:590.525
Hs Code.:

Synonyms:(R)-tert-butyl 2-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate

Suppliers and Price of (R)-tert-butyl 2-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(R)-tert-Butyl2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate 97%
100mg
$ 400.00

Alichem
(R)-tert-Butyl2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate
100mg
$ 424.00

Total 1 raw suppliers

Chemical Property of (R)-tert-butyl 2-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate

Chemical Property:

Boiling Point:690.5±55.0 °C(Predicted)
Density:1.39±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(R)-tert-Butyl2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate 97% ^*data from reagent suppliers

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Pictogram(s):
Hazard Codes:

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Useful:

Technology Process of (R)-tert-butyl 2-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate

There total 5 articles about (R)-tert-butyl 2-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 877399-49-0
3-[(R)-1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-ylamine

: 1421270-72-5
tert-butyl 2-(4-iodo-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate

: 1421270-73-6
(R)-tert-butyl 2-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; at 80 ℃; for 24h; Inert atmosphere;

Reference yield:

: 240401-28-9
2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

: 1421270-73-6
(R)-tert-butyl 2-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; triethylamine / dichloromethane / 26 h / 0 - 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.75 h / 0 - 20 °C / Inert atmosphere

2.2: 19 h / 20 - 80 °C

3.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 24 h / 80 °C / Inert atmosphere

With dmap; bis-triphenylphosphine-palladium(II) chloride; sodium hydride; sodium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 614729-59-8
2-((methylsulfonyl)oxy)-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

: 1421270-73-6
(R)-tert-butyl 2-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.75 h / 0 - 20 °C / Inert atmosphere

1.2: 19 h / 20 - 80 °C

2.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 24 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium hydride; sodium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;