(S)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol

Base Information

Chemical Name:(S)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol
CAS No.:1004791-26-7
Molecular Formula:C₁₂H₁₆ClNO₂
Molecular Weight:241.718
Hs Code.:

Synonyms:(S)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (S)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol

There total 7 articles about (S)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1004791-25-6
4-nitrobenzoic acid (S)-1-[(3R,5R)-5-(4-chlorophenyl)morpholine-3-yl]ethyl ester

: 1004791-26-7
(S)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 1h;

Reference yield:

: 1004791-09-6
(R)-5-((R)-1-benzyloxyethyl)morpholine-3-one

: 1004791-26-7
(S)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dmap / acetonitrile / 4 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: sodium hydroxide; water / methanol / 3 h / 20 °C

2.2: pH 4

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: tetrahydrofuran / 1 h / -40 - 0 °C

5.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

5.2: 0 - 20 °C

6.1: trimethylsilyl iodide / dichloromethane / 140 h / 20 °C

7.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2.5 h / 0 - 20 °C

8.1: methanol; sodium methylate / 1 h / 20 °C

With hydrogenchloride; methanol; sodium hydroxide; trimethylsilyl iodide; di-isopropyl azodicarboxylate; water; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; dmap; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1004791-10-9
((2R,3R)-3-benzyloxy-2-t-butoxycarbonylaminobutoxy)acetic acid t-butyl ester

: 1004791-26-7
(S)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

1.2: 1 h / 20 °C

1.3: 0 °C

2.1: triethylamine / dmap / acetonitrile / 4 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: sodium hydroxide; water / methanol / 3 h / 20 °C

3.2: pH 4

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: tetrahydrofuran / 1 h / -40 - 0 °C

6.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

6.2: 0 - 20 °C

7.1: trimethylsilyl iodide / dichloromethane / 140 h / 20 °C

8.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2.5 h / 0 - 20 °C

9.1: methanol; sodium methylate / 1 h / 20 °C

With hydrogenchloride; methanol; sodium hydroxide; trimethylsilyl iodide; di-isopropyl azodicarboxylate; water; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; dmap; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;