(R)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol

Base Information

Chemical Name:(R)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol
CAS No.:1004791-24-5
Molecular Formula:C₁₂H₁₆ClNO₂
Molecular Weight:241.718
Hs Code.:

Synonyms:(R)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol

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Chemical Property of (R)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol

Chemical Property:

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Technology Process of (R)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol

There total 7 articles about (R)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1004791-23-4
(3R,5R)-3-((R)-1-benzyloxyethyl)-5-(4-chlorophenyl)morpholine

: 1004791-24-5
(R)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol

Guidance literature:: (3R,5R)-3-((R)-1-benzyloxyethyl)-5-(4-chlorophenyl)morpholine; With trimethylsilyl iodide; In dichloromethane; at 20 ℃; for 144h;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

: 1004791-10-9
((2R,3R)-3-benzyloxy-2-t-butoxycarbonylaminobutoxy)acetic acid t-butyl ester

: 1004791-24-5
(R)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

1.2: 1 h / 20 °C

1.3: 0 °C

2.1: triethylamine / dmap / acetonitrile / 4 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: sodium hydroxide; water / methanol / 3 h / 20 °C

3.2: pH 4

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: tetrahydrofuran / 1 h / -40 - 0 °C

6.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

6.2: 0 - 20 °C

7.1: trimethylsilyl iodide / dichloromethane / 140 h / 20 °C

With hydrogenchloride; sodium hydroxide; trimethylsilyl iodide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dmap; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1004791-09-6
(R)-5-((R)-1-benzyloxyethyl)morpholine-3-one

: 1004791-24-5
(R)-1-[(3R,5R)-5-(4-chlorophenyl)-morpholine-3-yl]ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dmap / acetonitrile / 4 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: sodium hydroxide; water / methanol / 3 h / 20 °C

2.2: pH 4

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: tetrahydrofuran / 1 h / -40 - 0 °C

5.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

5.2: 0 - 20 °C

6.1: trimethylsilyl iodide / dichloromethane / 140 h / 20 °C

With hydrogenchloride; sodium hydroxide; trimethylsilyl iodide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; dmap; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;