(1R,7S)-3-(2-bromo-6-methoxyphenyl)-1,10,10-trimethyl-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-diene

Base Information

• Chemical Name: (1R,7S)-3-(2-bromo-6-methoxyphenyl)-1,10,10-trimethyl-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-diene
• CAS No.: 1319741-73-5
• Molecular Formula: C₁₈H₂₁BrN₂O
• Molecular Weight: 361.282
• Mol file: 1319741-73-5.mol

Synonyms:(1R,7S)-3-(2-bromo-6-methoxyphenyl)-1,10,10-trimethyl-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-diene

Chemical Property of (1R,7S)-3-(2-bromo-6-methoxyphenyl)-1,10,10-trimethyl-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-diene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,7S)-3-(2-bromo-6-methoxyphenyl)-1,10,10-trimethyl-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-diene

There total 5 articles about (1R,7S)-3-(2-bromo-6-methoxyphenyl)-1,10,10-trimethyl-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-diene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R)-3-(2-(2-bromo-6-methoxyphenyl)hydrazono)methylcamphor (1319741-77-9) → (1R,7S)-3-(2-bromo-6-methoxyphenyl)-1,10,10-trimethyl-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2(6),4-diene (1319741-73-5)

Guidance literature:

With hydrogen bromide; acetic acid; In water; at 80 ℃; for 2h;

DOI:10.1016/j.tetasy.2011.11.001

Reference yield:

C19H25BrN2O → (1R,7S)-3-(2-bromo-6-methoxyphenyl)-1,10,10-trimethyl-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2(6),4-diene (1319741-73-5)

Guidance literature:

With hydrogen bromide; In water; acetic acid; at 80 ℃; for 2h;

DOI:10.1134/S1070428011060224

Reference yield:

(2-bromo-6-methoxyphenyl)hydrazine (1319741-72-4) → (1R,7S)-3-(2-bromo-6-methoxyphenyl)-1,10,10-trimethyl-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2(6),4-diene (1319741-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 2 h

2: hydrogen bromide / water; acetic acid / 2 h / 80 °C

With hydrogen bromide; In methanol; water; acetic acid;

DOI:10.1134/S1070428011060224

upstream raw materials:

(2-bromo-6-methoxyphenyl)hydrazine

(1R)-3-(2-(2-bromo-6-methoxyphenyl)hydrazono)methylcamphor

2-bromo-6-methoxyphenylamine

Downstream raw materials:

(1R,7S)-3-(2-diphenylphosphino-6-methoxyphenyl)-1,10,10-trimethyl-3,4-diazatricyclo[5.2.1.0(2,6)]-deca-2⁽⁶⁾,4-diene

(4S,7R)-7,8,8-trimethyl-1-[2-(di-o-tolylphosphino)-6-methoxyphenyl]-4,5,6,7-tetrahydro-4,7-methano-1H-indazole

(4S,7R)-7,8,8-trimethyl-1-[2-bis(3,5-ditrifluoromethylphenyl)phosphino-6-methoxyphenyl]-4,5,6,7-tetrahydro-4,7-methano-1H-indazole

(4S,7R)-7,8,8-trimethyl-1-(2-dicyclohexylphosphino-6-methoxyphenyl)-4,5,6,7-tetrahydro-4,7-methano-1H-indazole