2-Bromo-6-methoxyaniline

Base Information

• Chemical Name: 2-Bromo-6-methoxyaniline
• CAS No.: 5473-01-8
• Molecular Formula: C7H8BrNO
• Molecular Weight: 202.051
• Hs Code.: 2922299090
• NSC Number: 29554
• DSSTox Substance ID: DTXSID60283074
• Wikidata: Q82017518
• Mol file: 5473-01-8.mol

Synonyms:2-bromo-6-methoxyaniline;5473-01-8;2-Bromo-6-methoxy-phenylamine;2-Bromo-6-methoxybenzenamine;Benzenamine, 2-bromo-6-methoxy-;2-Amino-3-bromoanisole;2-BROMO-6-METHOXY-ANILINE;NSC29554;2-bromo-6-methoxyphenylamine;SCHEMBL103597;DTXSID60283074;UDCXBOHQMWRTDN-UHFFFAOYSA-N;CL9145;MFCD08741448;NSC-29554;AKOS015999243;PS-4880;SB37619;CS-0033843;EN300-154072;J-508473;W-204296

Chemical Property of 2-Bromo-6-methoxyaniline

Chemical Property:

• Vapor Pressure: 0.0206mmHg at 25°C
• Boiling Point: 251.3°C at 760 mmHg
• PKA: 2.48±0.10(Predicted)
• Flash Point: 105.8°C
• PSA: 35.25000
• Density: 1.531g/cm³
• LogP: 2.62110
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 200.97893
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

95% ^*data from raw suppliers

2-Bromo-6-methoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=CC=C1)Br)N

Technology Process of 2-Bromo-6-methoxyaniline

There total 3 articles about 2-Bromo-6-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-methoxy-phenylamine (90-04-0) → 2-bromo-6-methoxyphenylamine (5473-01-8)

Guidance literature:

With bromine; In acetic acid; ethyl acetate;

Reference yield: 12.0%

2-methoxy-phenylamine (90-04-0) → 3,4-dibromo-2-methoxybenzenamine (1141892-43-4) + 4-bromo-2-methoxyaniline (59557-91-4) + 2-bromo-6-methoxyphenylamine (5473-01-8)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1139/V08-176

Reference yield:

bromine (7726-95-6) + 2-methoxy-phenylamine (90-04-0) + acetic acid (64-19-7,77671-22-8) → 2-bromo-6-methoxyphenylamine (5473-01-8)

Guidance literature:

upstream raw materials:

bromine

2-methoxy-phenylamine

acetic acid

Downstream raw materials:

2-amino-3-bromophenol

(1R,7S)-3-(2-bromo-6-methoxyphenyl)-1,10,10-trimethyl-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-diene

(1R,7S)-3-(2-bromo-6-methoxyphenyl)-1,5,10,10-tetramethyl-3,4-diazatricyclo[5.2.1.0(2,6)]deca-2⁽⁶⁾,4-diene

(1R,7S)-3-(2-diphenylphosphino-6-methoxyphenyl)-1,10,10-trimethyl-3,4-diazatricyclo[5.2.1.0(2,6)]-deca-2⁽⁶⁾,4-diene

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