ethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)acetate

Base Information

Chemical Name:ethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)acetate
CAS No.:1403881-38-8
Molecular Formula:C₂₃H₁₈BrF₅N₂O₆
Molecular Weight:593.302
Hs Code.:

Synonyms:ethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)acetate

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Chemical Property of ethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)acetate

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Technology Process of ethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)acetate

There total 6 articles about ethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 623-73-4
diazoacetic acid ethyl ester

: 1403880-91-0
3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

: 1403881-38-8
ethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)acetate

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 4h; Cooling with ice;

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 1403881-38-8
ethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)acetate

Guidance literature:: Multi-step reaction with 8 steps

1: 2 h / 130 °C

2: sodium tetrahydroborate / methanol / 2 h / Cooling with ice; Reflux

3: triethylamine / dichloromethane / 20 °C / Cooling with ice

4: N-Bromosuccinimide; acetic acid / 20 °C

5: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

6: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

7: potassium carbonate / methanol / 1 h / 20 °C

8: boron trifluoride diethyl etherate / dichloromethane / 4 h / 20 °C / Cooling with ice

With sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; potassium carbonate; acetic acid; triethylamine; In methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1403883-97-5
2-(4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl acetate

: 1403881-38-8
ethyl 2-(2-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-(3-carbamoyl-2,4-difluorophenoxy)ethoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; acetic acid / 20 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

4: potassium carbonate / methanol / 1 h / 20 °C

5: boron trifluoride diethyl etherate / dichloromethane / 4 h / 20 °C / Cooling with ice

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; potassium carbonate; acetic acid; In methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;