(S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline benzyl ester

Base Information

Chemical Name:(S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline benzyl ester
CAS No.:850742-56-2
Molecular Formula:C₂₉H₃₄N₄O₇
Molecular Weight:550.612
Hs Code.:

Synonyms:(S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline benzyl ester

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Chemical Property of (S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline benzyl ester

Chemical Property:

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Technology Process of (S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline benzyl ester

There total 4 articles about (S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 95922-37-5
(S)-N-tert-butoxycarbonyl-δ-bromo-norvaline benzyl ester

: 149411-91-6
N-benzyloxycarbonyl cytosine

: 850742-56-2
(S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline benzyl ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; for 72h;
DOI:10.1039/b411545g

Reference yield:

: 30924-93-7
Boc-Glu-OBn

: 850742-56-2
(S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethylmorpholine / tetrahydrofuran / 0.17 h / -10 °C

2: 5.03 g / NaBH₄ / tetrahydrofuran; methanol / 0.75 h / -10 - 20 °C

3: 53 percent / CBr₄; PPh₃ / CH₂Cl₂

4: 69 percent / K₂CO₃; tetrabutylammonium iodide / dimethylformamide / 72 h

With N-ethylmorpholine;; sodium tetrahydroborate; carbon tetrabromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b411545g

Reference yield:

: (S)-2-tert-Butoxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid benzyl ester

: 850742-56-2
(S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 5.03 g / NaBH₄ / tetrahydrofuran; methanol / 0.75 h / -10 - 20 °C

2: 53 percent / CBr₄; PPh₃ / CH₂Cl₂

3: 69 percent / K₂CO₃; tetrabutylammonium iodide / dimethylformamide / 72 h

With sodium tetrahydroborate; carbon tetrabromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b411545g