(S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline

Base Information

Chemical Name:(S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline
CAS No.:850742-34-6
Molecular Formula:C₂₂H₂₈N₄O₇
Molecular Weight:460.487
Hs Code.:

Synonyms:(S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline

Chemical Property:

Purity/Quality:

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Technology Process of (S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline

There total 5 articles about (S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 850742-56-2
(S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline benzyl ester

: 850742-34-6
(S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 24h;
DOI:10.1039/b411545g

Reference yield:

: 95922-37-5
(S)-N-tert-butoxycarbonyl-δ-bromo-norvaline benzyl ester

: 850742-34-6
(S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / K₂CO₃; tetrabutylammonium iodide / dimethylformamide / 72 h

2: 63 percent / aq. NaOH / dioxane / 24 h / 20 °C

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1039/b411545g

Reference yield:

: 30924-93-7
Boc-Glu-OBn

: 850742-34-6
(S)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethylmorpholine / tetrahydrofuran / 0.17 h / -10 °C

2: 5.03 g / NaBH₄ / tetrahydrofuran; methanol / 0.75 h / -10 - 20 °C

3: 53 percent / CBr₄; PPh₃ / CH₂Cl₂

4: 69 percent / K₂CO₃; tetrabutylammonium iodide / dimethylformamide / 72 h

5: 63 percent / aq. NaOH / dioxane / 24 h / 20 °C

With N-ethylmorpholine;; sodium hydroxide; sodium tetrahydroborate; carbon tetrabromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b411545g