Technology Process of phenylmethyl (1-{[(2R)-4,9-dioxo-1,2,8,9-tetrahydro-4H,7H-imidazo[1,2,3-ij]-1,8-naphthyridin-2-yl]methyl}-4-methyl-4-piperidinyl)carbamate
There total 13 articles about phenylmethyl (1-{[(2R)-4,9-dioxo-1,2,8,9-tetrahydro-4H,7H-imidazo[1,2,3-ij]-1,8-naphthyridin-2-yl]methyl}-4-methyl-4-piperidinyl)carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine;
In
acetonitrile;
for 6h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogen / palladium on activated charcoal / ethanol / 90 h / 20 °C / 760.05 Torr
2.1: hydrogenchloride; water / 6 h / 80 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
3.2: 1 h / 0 - 20 °C
4.1: N,N-dimethyl-formamide / 6 h / 120 °C
5.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
6.1: pyridine / acetonitrile / 6 h / Heating / reflux
With
pyridine; hydrogenchloride; water; hydrogen; sodium hydride; triethylamine;
palladium on activated charcoal;
In
ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.25 h
1.2: 24 h / Heating / reflux
2.1: n-butyllithium / tetrahydrofuran / -78 - 0 °C
2.2: -78 - 20 °C
3.1: N-Methyldicyclohexylamine / tris-(dibenzylideneacetone)dipalladium(0); bis(tri-t-butylphosphine)palladium(0) / 1,4-dioxane / 7 h / 80 - 120 °C
4.1: hydrogen / palladium on activated charcoal / ethanol / 90 h / 20 °C / 760.05 Torr
5.1: hydrogenchloride; water / 6 h / 80 °C
6.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
6.2: 1 h / 0 - 20 °C
7.1: N,N-dimethyl-formamide / 6 h / 120 °C
8.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
9.1: pyridine / acetonitrile / 6 h / Heating / reflux
With
pyridine; hydrogenchloride; n-butyllithium; N-Methyldicyclohexylamine; water; hydrogen; sodium hydride; caesium carbonate; triethylamine;
tris-(dibenzylideneacetone)dipalladium(0); bis(tri-t-butylphosphine)palladium(0); palladium on activated charcoal; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
3.1: Heck Reaction;
