2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid

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Chemical Name:2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid
CAS No.:1245157-61-2
Molecular Formula:C₂₂H₂₆N₆O₃S
Molecular Weight:454.553
Hs Code.:

Synonyms:2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid

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Chemical Property of 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid

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Technology Process of 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid

There total 4 articles about 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.9%

: 1245157-52-1
methyl 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate

: 1245157-61-2
2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid

Guidance literature:: methyl 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate; With water; sodium hydroxide; at 60 - 80 ℃; for 4h;

With hydrogenchloride; In water; at 20 ℃; pH=2;

Reference yield:

: 1245157-45-2
methyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate

: 1245157-61-2
2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 20 °C / Reflux

2.1: sodium hydroxide; water / 4 h / 60 - 80 °C

2.2: 20 °C / pH 2

With water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In butan-1-ol;

Reference yield:

: 1161763-15-0
4-amino-6-bromo-2-methylpyrimidine

: 1245157-61-2
2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 4 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 20 °C / Reflux

3.1: sodium hydroxide; water / 4 h / 60 - 80 °C

3.2: 20 °C / pH 2

With water; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; butan-1-ol;