methyl 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate

Base Information

Chemical Name:methyl 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate
CAS No.:1245157-52-1
Molecular Formula:C₂₃H₂₈N₆O₃S
Molecular Weight:468.58
Hs Code.:

Synonyms:methyl 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate

Suppliers and Price of methyl 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate

There total 2 articles about methyl 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1161763-15-0
4-amino-6-bromo-2-methylpyrimidine

: 1245157-52-1
methyl 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 4 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 20 °C / Reflux

With sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; butan-1-ol;

Reference yield:

: 72605-86-8
2-chlorothiazole-5-carboxylic acid methyl ester

: 1245157-52-1
methyl 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 20 °C / Reflux

2.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 20 °C / Reflux

With sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; mineral oil; butan-1-ol;

Reference yield: 97.9%

: 1245157-52-1
methyl 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate

: 1245157-61-2
2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid

Guidance literature:: methyl 2-(6-(4-(2-benzoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate; With water; sodium hydroxide; at 60 - 80 ℃; for 4h;

With hydrogenchloride; In water; at 20 ℃; pH=2;