methyl 6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Base Information

Chemical Name:methyl 6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
CAS No.:1336964-72-7
Molecular Formula:C₂₈H₂₉ClF₃N₃O₃
Molecular Weight:548.005
Hs Code.:

Synonyms:methyl 6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

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Chemical Property of methyl 6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

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Technology Process of methyl 6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

There total 6 articles about methyl 6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1336964-71-6
methyl 3-(bromomethyl)-6-chloro-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

: 53617-35-9
4-(piperidin-4-yl)morpholine

: 1336964-72-7
methyl 6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: 4-(piperidin-4-yl)morpholine; With potassium carbonate; In dichloromethane; at 20 ℃; for 0.5h;

methyl 3-(bromomethyl)-6-chloro-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 106-47-8
4-chloro-aniline

: 1336964-72-7
methyl 6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate / water / 3 h / 20 °C / Reflux

2.1: sulfuric acid / 1 h / 70 °C

3.1: hydrogenchloride; acetic acid / water / 48 h / 75 - 110 °C

4.1: thionyl chloride / Heating

4.2: 18 h / 20 °C

5.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Reflux

6.1: potassium carbonate / dichloromethane / 0.5 h / 20 °C

6.2: 24 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; thionyl chloride; sulfuric acid; hydroxylamine hydrochloride; potassium carbonate; acetic acid; sodium sulfate; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; water;

Reference yield:

: 17630-76-1
5-chloroindole 2,3-dione

: 1336964-72-7
methyl 6-chloro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; acetic acid / water / 48 h / 75 - 110 °C

2.1: thionyl chloride / Heating

2.2: 18 h / 20 °C

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Reflux

4.1: potassium carbonate / dichloromethane / 0.5 h / 20 °C

4.2: 24 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; thionyl chloride; potassium carbonate; acetic acid; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; water;