6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydro-2-naphthalenecarbaldehyde

Base Information

• Chemical Name: 6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydro-2-naphthalenecarbaldehyde
• CAS No.: 891859-41-9
• Molecular Formula: C₂₃H₂₆O₃
• Molecular Weight: 350.458
• Mol file: 891859-41-9.mol

Synonyms:6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydro-2-naphthalenecarbaldehyde

Chemical Property of 6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydro-2-naphthalenecarbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydro-2-naphthalenecarbaldehyde

There total 7 articles about 6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydro-2-naphthalenecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

6-hydroxy-1-methyl-3,4-dihydro-naphthalene-2-carbaldehyde (847585-92-6) + (2-methoxy-4-propylphenyl)methanol (891859-11-3) → 6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydro-2-naphthalenecarbaldehyde (891859-41-9)

Guidance literature:

(2-methoxy-4-propylphenyl)methanol; With phosphorus tribromide; In diethyl ether; at 0 ℃; for 1.5h;

6-hydroxy-1-methyl-3,4-dihydro-naphthalene-2-carbaldehyde; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

DOI:10.1021/acs.jmedchem.7b00785

Reference yield:

6-hydroxy-1-methyl-3,4-dihydro-naphthalene-2-carbaldehyde (847585-92-6) + 1-(chloromethyl)-2-methoxy-4-propylbenzene (891859-40-8) → 6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydro-2-naphthalenecarbaldehyde (891859-41-9)

Guidance literature:

With potassium phosphate; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

Reference yield:

2-hydroxy-4-propylbenzoic acid (119006-58-5) → 6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydro-2-naphthalenecarbaldehyde (891859-41-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C

3.1: phosphorus tribromide / diethyl ether / 1.5 h / 0 °C

3.2: 14 h / 20 °C

With lithium aluminium tetrahydride; phosphorus tribromide; potassium carbonate; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.7b00785

upstream raw materials:

6-hydroxy-1-methyl-3,4-dihydro-naphthalene-2-carbaldehyde

1-(chloromethyl)-2-methoxy-4-propylbenzene

(2-methoxy-4-propylphenyl)methanol

3-n-propylphenol