C₂₉H₂₇ClN₂O₅

Base Information

• Chemical Name: C₂₉H₂₇ClN₂O₅
• CAS No.: 1423689-60-4
• Molecular Formula: C₂₉H₂₇ClN₂O₅
• Molecular Weight: 518.997
• Mol file: 1423689-60-4.mol

Synonyms:C₂₉H₂₇ClN₂O₅

Chemical Property of C₂₉H₂₇ClN₂O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₂₇ClN₂O₅

There total 8 articles about C₂₉H₂₇ClN₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester (859169-20-3) + [3-(4-bromo-phenyl)-5-methyl-isoxazol-4-yl]-carbamic acid (R)-1-(2-chloro-phenyl)-ethyl ester (1265631-09-1) → C29H27ClN2O5 (1423689-60-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; triphenylphosphine; In 1,4-dioxane; water; at 90 ℃; for 3h; Inert atmosphere;

Reference yield:

1-(2-chlorophenyl)ethanone (2142-68-9) → C29H27ClN2O5 (1423689-60-4)

Guidance literature:

Multi-step reaction with 3 steps

1: (S)-tetrahydro-1-butyl-3,3-diphenyl-1H,3H-pyrrolo{2,1-c}{1,3,2}oxazaborole; dimethylsulfide borane complex / tetrahydrofuran / 0.5 h / 20 °C

2: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 80 °C

3: triphenylphosphine; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dimethylsulfide borane complex; diphenyl phosphoryl azide; potassium carbonate; triethylamine; triphenylphosphine; (S)-tetrahydro-1-butyl-3,3-diphenyl-1H,3H-pyrrolo{2,1-c}{1,3,2}oxazaborole; In tetrahydrofuran; 1,4-dioxane; water; toluene;

Reference yield:

4-bromobenzaldehyde oxime (25062-46-8,40979-16-6,34158-73-1) → C29H27ClN2O5 (1423689-60-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 15 - 20 °C

2.1: sodium methylate / methanol / 0.67 h / 0 - 25 °C

3.1: water; sodium hydroxide / tetrahydrofuran / 3 h / 20 °C

3.2: pH Ca_. 3 / Cooling with ice

4.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 80 °C

5.1: triphenylphosphine; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; diphenyl phosphoryl azide; water; sodium methylate; potassium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

1-(2-chlorophenyl)ethanone

4-bromobenzaldehyde oxime

4-bromo-N-hydroxybenzenecarboximidoyl chloride

3-(p-bromophenyl)-5-methylisoxazole-4-carboxylic acid ethyl ester

Downstream raw materials:

(4'-{4-[(R)-1-(2-chloro-phenyl)-ethoxycarbonylamino]-5-methyl-isoxazol-3-yl}-biphenyl-4-yl)-acetic acid

Refernces