1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl) [1,1'-biphenyl]-4-yl]-3-methyl-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl) [1,1'-biphenyl]-4-yl]-3-methyl-1H-pyrazole-5-carboxamide
CAS No.:209958-59-8
Molecular Formula:C₂₈H₂₇N₅O₃S
Molecular Weight:513.62
Hs Code.:

Synonyms:1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl) [1,1'-biphenyl]-4-yl]-3-methyl-1H-pyrazole-5-carboxamide

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Chemical Property of 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl) [1,1'-biphenyl]-4-yl]-3-methyl-1H-pyrazole-5-carboxamide

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Technology Process of 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl) [1,1'-biphenyl]-4-yl]-3-methyl-1H-pyrazole-5-carboxamide

There total 8 articles about 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl) [1,1'-biphenyl]-4-yl]-3-methyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 193006-34-7
4-(2'-tert-butylaminosulfonylphenyl)aniline

: 209917-95-3
1-(3-cyanophenyl)-3-methylpyrazol-5-yl carboxylic acid chloride

: 209958-59-8
1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl) [1,1'-biphenyl]-4-yl]-3-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jm000409z

Reference yield:

: 193006-34-7
4-(2'-tert-butylaminosulfonylphenyl)aniline

: 209958-57-6
2-(3-cyano-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

: 209958-59-8
1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl) [1,1'-biphenyl]-4-yl]-3-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: 4-(2'-tert-butylaminosulfonylphenyl)aniline; With trimethylaluminum; In hexane; dichloromethane; at 20 ℃; for 0.25h;

2-(3-cyano-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester; In hexane; dichloromethane; at 40 ℃; for 18h;
DOI:10.1021/jm020578e

Reference yield:

: 17672-26-3
3-cyanophenyl hydrazine

: 209958-59-8
1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl) [1,1'-biphenyl]-4-yl]-3-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 5 h / Heating

2.1: Me₃Al / CH₂Cl₂; hexane / 0.25 h / 20 °C

2.2: CH₂Cl₂; hexane / 18 h / 40 °C

With trimethylaluminum; In ethanol; hexane; dichloromethane;
DOI:10.1021/jm020578e