JUSTICIDIN G(SH)

Base Information

• Chemical Name: JUSTICIDIN G(SH)
• CAS No.: 145971-08-0
• Molecular Formula: C₂₂H₁₈O₈
• Molecular Weight: 410.38
• Mol file: 145971-08-0.mol

Synonyms:6'-HydroxyjusticidinA; Justicidin G; Justicidin G (Justicia procumbens)

Chemical Property of JUSTICIDIN G(SH)

Chemical Property:

• Melting Point: 218～220℃
• Boiling Point: 681.1±55.0 °C(Predicted)
• PKA: 8.65±0.20(Predicted)
• PSA: 92.68000
• Density: 1.429±0.06 g/cm3(Predicted)
• LogP: 3.63730

Purity/Quality:

98% ^*data from raw suppliers

JUSTICIDIN G 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of JUSTICIDIN G(SH)

There total 3 articles about JUSTICIDIN G(SH) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.9%

6'-benzyloxyjusticidin A (1394124-92-5) → 6'-hydroxy-justicidin A (145971-08-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In water; for 3h; under 760.051 Torr;

DOI:10.1080/10286020.2011.653561

Reference yield:

6'-benzyloxydiphyllin (1394124-91-4) → 6'-hydroxy-justicidin A (145971-08-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 1 h / Reflux

2: palladium 10% on activated carbon; hydrogen / water / 3 h / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In water; acetone;

DOI:10.1080/10286020.2011.653561

Reference yield:

diethyl 1-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-4-hydroxy-6,7-dimethoxynaphthalene-2,3-dicarboxylate (1394124-90-3) → 6'-hydroxy-justicidin A (145971-08-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 3 h / Reflux

1.2: 1 h / 20 °C / pH 2 - 3

2.1: potassium carbonate / acetone / 1 h / Reflux

3.1: palladium 10% on activated carbon; hydrogen / water / 3 h / 760.05 Torr

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; water; acetone;

DOI:10.1080/10286020.2011.653561

upstream raw materials:

6'-benzyloxydiphyllin

6'-benzyloxyjusticidin A

diethyl 1-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-4-hydroxy-6,7-dimethoxynaphthalene-2,3-dicarboxylate