5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3-(2-(trifluoromethyl)-4-vinylphenyl)-1,2,4-oxadiazole

Base Information

Chemical Name:5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3-(2-(trifluoromethyl)-4-vinylphenyl)-1,2,4-oxadiazole
CAS No.:1265323-66-7
Molecular Formula:C₂₁H₁₁F₆N₃O₂
Molecular Weight:451.328
Hs Code.:

Synonyms:5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3-(2-(trifluoromethyl)-4-vinylphenyl)-1,2,4-oxadiazole

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Chemical Property of 5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3-(2-(trifluoromethyl)-4-vinylphenyl)-1,2,4-oxadiazole

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Technology Process of 5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3-(2-(trifluoromethyl)-4-vinylphenyl)-1,2,4-oxadiazole

There total 6 articles about 5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3-(2-(trifluoromethyl)-4-vinylphenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1265323-66-7
5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3-(2-(trifluoromethyl)-4-vinylphenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2: 1,1-dichloroethane / 20 - 70 °C

3: 2,2,6,6-tetramethyl-piperidine-N-oxyl; disodium hydrogenphosphate; sodium chlorite; sodium dihydrogenphosphate / acetonitrile; water / 20 - 35 °C

4: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; disodium hydrogenphosphate; sodium dihydrogenphosphate; N-chloro-succinimide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In 1,1-dichloroethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1236188-80-9
3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid

: 1265750-12-6
N'-hydroxy-2-(trifluoromethyl)-4-vinylbenzimidamide

: 1265323-66-7
5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3-(2-(trifluoromethyl)-4-vinylphenyl)-1,2,4-oxadiazole

Guidance literature:: 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid; N'-hydroxy-2-(trifluoromethyl)-4-vinylbenzimidamide; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 191165-13-6
4-bromo-2-(trifluoromethyl)benzonitrile

: 1265323-66-7
5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3-(2-(trifluoromethyl)-4-vinylphenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: cesium fluoride; tributylphosphine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; hexane / 80 °C

1.2: 1 h

2.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / isopropyl alcohol / 85 °C

3.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With tributylphosphine; hydroxylamine hydrochloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; cesium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In hexane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;