1236188-80-9

Basic information

• Product Name: 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid
• Synonyms: 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid
• CAS NO: 1236188-80-9
• Molecular Weight: 257.169
• Mol File: 1236188-80-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid(1236188-80-9)
• EPA Substance Registry System: 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid(1236188-80-9)

Safety Data

• Hazardous Substances Data: 1236188-80-9(Hazardous Substances Data)

Upstream product

• 1236188-81-0 ethyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate 
• 104721-34-8 methyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate 
• 698-16-8 benzohydroximoyl chloride 
• 932-90-1 syn-benzaldehyde oxime 
• 934-16-7 phenylhydroxamoyl chloride 
• 1236188-79-6 (3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)methanol 

Downstream Products

• 1236189-50-6 tert-butyl 1-(3-chloro-4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate 
• 1236189-53-9 tert-butyl 1-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)-3-(trifluoromethyl)benzyl)azetidine-3-carboxylate 
• 1236188-83-2 3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl fluoride 
• 1265323-50-9 ethyl (3S)-1-[(2S)-2-hydroxy-2-(4-{5-[3-phenyl-4-(trifluoromethyl)isoxazol-5-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethyl]piperidine-3-carboxylate 
• 1265324-15-9 3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl chloride 
• 1265323-61-2 ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetate 
• 1265322-15-3 1-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylic acid tetrabutylammonium salt 
• 1265323-67-8 3-(4-(oxiran-2-yl)-2-(trifluoromethyl)phenyl)-5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole 
• 1265323-68-9 5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-3-(4-vinylphenyl)-1,2,4-oxadiazole 
• 1265323-69-0 3-(4-(oxiran-2-yl)phenyl)-5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole 
• 1265322-29-9 2-(3-(hydroxymethyl)piperidin-1-yl)-1-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethanol 
• 1265322-31-3 2-(3-(2-hydroxyethyl)piperidin-1-yl)-1-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethanol 
• 1265322-33-5 5-hydroxy-1-(2-hydroxy-2-(4-(5-(3-phenyl-4-(trifmoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid 

Relevant articles and documents

Regioselective Epoxide Ring Opening for the Stereospecific Scale-Up Synthesis of BMS-960, A Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist

This article presents a stereospecific scale-up synthesis of (S)-1-((S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid (BMS-960), a potent and selective isoxazole-containing S1P

An Efficient Scale-Up Synthesis of BMS-520, a Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist

This article reports an efficient scale-up synthesis of 1-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid (BMS-520), a potent and selective isoxazole-containing S1P1 receptor agonist. Th

Synthesis of ethyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate via regioselective dipolar cycloaddition

Efforts to prepare ethyl 3-phenyl-4-(trifluoromethyl)isoxazole-5- carboxylate (1) by developing a regioselective 1,3-dipolar cycloaddition between phenyl nitrile oxide and various 4,4,4-trifluoromethyl crotonates are described. The substitution at the C2-position of crotonate dipolarophile 4 significantly influenced the regiochemistry and yield of the cycloaddition. Enol and enol ether-based crotonates underwent regioselective cycloadditions with phenyl nitrile oxide to provide 4-trifluoromethyl isoxazoles in good yields.