6-cyano-7,8,9,10-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-5-sulfanylacetophenone

Base Information

Chemical Name:6-cyano-7,8,9,10-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-5-sulfanylacetophenone
CAS No.:1269792-77-9
Molecular Formula:C₁₉H₁₆N₄OS
Molecular Weight:348.428
Hs Code.:

Synonyms:6-cyano-7,8,9,10-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-5-sulfanylacetophenone

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Chemical Property of 6-cyano-7,8,9,10-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-5-sulfanylacetophenone

Chemical Property:

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Technology Process of 6-cyano-7,8,9,10-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-5-sulfanylacetophenone

There total 3 articles about 6-cyano-7,8,9,10-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-5-sulfanylacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1269792-65-5
5-thioxo-7,8,9,10-tetrahydro-1H-[1,2,4]triazolo[3,4-a]isoquinoline-6-carbonitrile

: 70-11-1
α-bromoacetophenone

: 1269792-77-9
6-cyano-7,8,9,10-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-5-sulfanylacetophenone

Guidance literature:: With sodium acetate; In ethanol; for 0.25h;
DOI:10.1016/j.ejmech.2010.11.036

Reference yield:

: 1269792-60-0
1-hydrazino-3-thioxo-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

: 1269792-77-9
6-cyano-7,8,9,10-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-5-sulfanylacetophenone

Guidance literature:: Multi-step reaction with 2 steps

1: 0.5 h / Reflux

2: sodium acetate / ethanol / 0.25 h

With sodium acetate; In ethanol;
DOI:10.1016/j.ejmech.2010.11.036

Reference yield:

: 50706-78-0
2,3,5,6,7,8-hexahydro-1-morpholin-4-yl-3-thioxo-isoquinoline-4-carbonitrile

: 1269792-77-9
6-cyano-7,8,9,10-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-5-sulfanylacetophenone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 2 h / Reflux

2: 0.5 h / Reflux

3: sodium acetate / ethanol / 0.25 h

With sodium acetate; hydrazine hydrate; In ethanol;
DOI:10.1016/j.ejmech.2010.11.036