2-methyl-N-{4-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}propanamide

Base Information

Chemical Name:2-methyl-N-{4-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}propanamide
CAS No.:1192576-19-4
Molecular Formula:C₁₉H₂₁N₅O₂S
Molecular Weight:383.474
Hs Code.:

Synonyms:2-methyl-N-{4-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}propanamide

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Chemical Property of 2-methyl-N-{4-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}propanamide

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Technology Process of 2-methyl-N-{4-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}propanamide

There total 4 articles about 2-methyl-N-{4-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1192574-05-2
4-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]-1,3-thiazol-2-amine

: 97-72-3
2-Methylpropionic anhydride

: 1192576-19-4
2-methyl-N-{4-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}propanamide

Guidance literature:: With triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; for 6.5h; Reflux;

Reference yield:

: 6919-61-5
N-methoxy-N-methylbenzamide

: 1192576-19-4
2-methyl-N-{4-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethylmagnesium bromide / diethyl ether; dichloromethane / 20 °C

1.2: 0 - 20 °C

2.1: pyridine; hydroxylamine hydrochloride / 75 h / 20 - 50 °C

3.1: caesium carbonate / potassium iodide / N,N-dimethyl-formamide / 101 h / 20 °C

4.1: triethylamine / N,N-dimethyl-formamide / 1,4-dioxane / 6.5 h / Reflux

With pyridine; ethylmagnesium bromide; hydroxylamine hydrochloride; caesium carbonate; triethylamine; N,N-dimethyl-formamide; potassium iodide; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1192575-99-7
N-hydroxy-1-(1-methyl-1H-imidazol-5-yl)-1-phenylmethanimine

: 1192576-19-4
2-methyl-N-{4-[({[(1-methyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / potassium iodide / N,N-dimethyl-formamide / 101 h / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 1,4-dioxane / 6.5 h / Reflux

With caesium carbonate; triethylamine; N,N-dimethyl-formamide; potassium iodide; In 1,4-dioxane; N,N-dimethyl-formamide;