2-Ethoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-phenol

Base Information

• Chemical Name: 2-Ethoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-phenol
• CAS No.: 222022-89-1
• Molecular Formula: C₁₇H₂₆O₂
• Molecular Weight: 262.392
• Mol file: 222022-89-1.mol

Synonyms:2-Ethoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-phenol

Chemical Property of 2-Ethoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Ethoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-phenol

There total 8 articles about 2-Ethoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-Benzyloxy-2-ethoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-benzene (222022-96-0) → 2-Ethoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-phenol (222022-89-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; under 760 Torr; Ambient temperature;

DOI:10.1016/S0040-4039(98)02487-3

Reference yield:

(S)-5-methyl-3-(1,2,2-trimethylcyclopentyl)benzene-1,2-diol (86996-95-4) → 2-Ethoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-phenol (222022-89-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / K₂CO₃ / acetone / Ambient temperature

2: 85 percent / Cs₂CO₃, Bzl(n-Bu)3NBr / acetone

3: 80 percent / H₂ / Pd/C (10 percent) / ethanol; ethyl acetate / 760 Torr / Ambient temperature

With hydrogen; benzyl tri-n-butylammonium bromide; potassium carbonate; caesium carbonate; palladium on activated charcoal; In ethanol; ethyl acetate; acetone;

DOI:10.1016/S0040-4039(98)02487-3

Reference yield:

(1'S)-3,4-dihydroxy-5-(1,2,2-trimethylcyclopentyl)benzaldehyde (185967-11-7) → 2-Ethoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-phenol (222022-89-1)

Guidance literature:

Multi-step reaction with 8 steps

1: 73 percent / K₂CO₃ / acetone / Ambient temperature

2: 95 percent / LiAlH₄ / tetrahydrofuran

3: C₂Br₂Cl₄, Ph₃P / CH₂Cl₂

4: LiAlH₄ / diethyl ether

5: 93 percent / BBr₃ / CH₂Cl₂ / 0 °C

6: 90 percent / K₂CO₃ / acetone / Ambient temperature

7: 85 percent / Cs₂CO₃, Bzl(n-Bu)3NBr / acetone

8: 80 percent / H₂ / Pd/C (10 percent) / ethanol; ethyl acetate / 760 Torr / Ambient temperature

With lithium aluminium tetrahydride; C₂Br₂Cl₄; hydrogen; benzyl tri-n-butylammonium bromide; boron tribromide; potassium carbonate; caesium carbonate; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; ethyl acetate; acetone;

DOI:10.1016/S0040-4039(98)02487-3

upstream raw materials:

1-Benzyloxy-2-ethoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-benzene

(S)-5-methyl-3-(1,2,2-trimethylcyclopentyl)benzene-1,2-diol

(1'S)-3,4-dihydroxy-5-(1,2,2-trimethylcyclopentyl)benzaldehyde

(1'S)-1,2-dimethoxy-5-methyl-3-(1',2',2'-trimethylcyclopentyl)benzene