{2-Bromo-3-[(1S,5S)-5-(tert-butyl-dimethyl-silanyloxy)-2-oxo-cyclohexyloxy]-4-methoxy-benzyl}-methyl-carbamic acid tert-butyl ester

Base Information

Chemical Name:{2-Bromo-3-[(1S,5S)-5-(tert-butyl-dimethyl-silanyloxy)-2-oxo-cyclohexyloxy]-4-methoxy-benzyl}-methyl-carbamic acid tert-butyl ester
CAS No.:137718-80-0
Molecular Formula:C₂₆H₄₂BrNO₆Si
Molecular Weight:572.612
Hs Code.:

Synonyms:{2-Bromo-3-[(1S,5S)-5-(tert-butyl-dimethyl-silanyloxy)-2-oxo-cyclohexyloxy]-4-methoxy-benzyl}-methyl-carbamic acid tert-butyl ester

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Chemical Property of {2-Bromo-3-[(1S,5S)-5-(tert-butyl-dimethyl-silanyloxy)-2-oxo-cyclohexyloxy]-4-methoxy-benzyl}-methyl-carbamic acid tert-butyl ester

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Technology Process of {2-Bromo-3-[(1S,5S)-5-(tert-butyl-dimethyl-silanyloxy)-2-oxo-cyclohexyloxy]-4-methoxy-benzyl}-methyl-carbamic acid tert-butyl ester

There total 7 articles about {2-Bromo-3-[(1S,5S)-5-(tert-butyl-dimethyl-silanyloxy)-2-oxo-cyclohexyloxy]-4-methoxy-benzyl}-methyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 137718-77-5
(2-Bromo-3-hydroxy-4-methoxy-benzyl)-methyl-carbamic acid tert-butyl ester

: 137718-83-3
trans-2-bromo-4-(tert-butyldimethylsiloxy)cyclohexanone

: 137718-80-0
{2-Bromo-3-[(1S,5S)-5-(tert-butyl-dimethyl-silanyloxy)-2-oxo-cyclohexyloxy]-4-methoxy-benzyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: With sodium hydroxide; tetrabutylammomium bromide; In dichloromethane; water; for 36h; Ambient temperature;
DOI:10.1021/jo00028a066

Reference yield:

: 69125-55-9
4-hydroxy-1-methoxy-1-cyclohexene

: 137718-80-0
{2-Bromo-3-[(1S,5S)-5-(tert-butyl-dimethyl-silanyloxy)-2-oxo-cyclohexyloxy]-4-methoxy-benzyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / imidazole / dimethylformamide / 36 h / Ambient temperature

2: 1.) NBS, NaOAc, 2.) SiO₂ / 1.) THF, H₂O, 0 deg C, 4 h

3: 64 percent / NaOH / n-Bu₄NBr / H₂O; CH₂Cl₂ / 36 h / Ambient temperature

With 1H-imidazole; sodium hydroxide; N-Bromosuccinimide; sodium acetate; silica gel; tetrabutylammomium bromide; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00028a066

Reference yield:

: 137718-78-6
tert-butyl-(4-methoxycyclohex-3-enyloxy)dimethylsilane

: 137718-80-0
{2-Bromo-3-[(1S,5S)-5-(tert-butyl-dimethyl-silanyloxy)-2-oxo-cyclohexyloxy]-4-methoxy-benzyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NBS, NaOAc, 2.) SiO₂ / 1.) THF, H₂O, 0 deg C, 4 h

2: 64 percent / NaOH / n-Bu₄NBr / H₂O; CH₂Cl₂ / 36 h / Ambient temperature

With sodium hydroxide; N-Bromosuccinimide; sodium acetate; silica gel; tetrabutylammomium bromide; In dichloromethane; water;
DOI:10.1021/jo00028a066