dimethyl {3-[(tert-butoxycarbonyl)(tert-butoxycarbonyloxy)amino]-1-cyclohexen-1-yl}phosphonate

Base Information

• Chemical Name: dimethyl {3-[(tert-butoxycarbonyl)(tert-butoxycarbonyloxy)amino]-1-cyclohexen-1-yl}phosphonate
• CAS No.: 180294-88-6
• Molecular Formula: C₁₈H₃₂NO₈P
• Molecular Weight: 421.428
• Mol file: 180294-88-6.mol

Synonyms:dimethyl {3-[(tert-butoxycarbonyl)(tert-butoxycarbonyloxy)amino]-1-cyclohexen-1-yl}phosphonate

Chemical Property of dimethyl {3-[(tert-butoxycarbonyl)(tert-butoxycarbonyloxy)amino]-1-cyclohexen-1-yl}phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of dimethyl {3-[(tert-butoxycarbonyl)(tert-butoxycarbonyloxy)amino]-1-cyclohexen-1-yl}phosphonate

There total 1 articles about dimethyl {3-[(tert-butoxycarbonyl)(tert-butoxycarbonyloxy)amino]-1-cyclohexen-1-yl}phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N,N-di(tert-butoxycarbonyl)hydroxylamine (85006-25-3) + (3-hydroxy-1-cyclohexenyl)phosphonsaeure-dimethylester (128389-14-0) → diethyl hydrazodicarboxylate (4114-28-7) + Triphenylphosphine oxide (791-28-6) + dimethyl {3-[(tert-butoxycarbonyl)(tert-butoxycarbonyloxy)amino]-1-cyclohexen-1-yl}phosphonate (180294-88-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In toluene; at -20 ℃; for 1.5h;

DOI:10.1080/10426509608046350

Reference yield:

dimethyl {3-[(tert-butoxycarbonyl)(tert-butoxycarbonyloxy)amino]-1-cyclohexen-1-yl}phosphonate (180294-88-6) → dimethyl {[3-(N-acetyl-N-hydroxy)amino]-1-cyclohexen-1-yl}phosphonate

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 6 h / Ambient temperature

2: 1.) NaHCO₃, 2.) pyridine / 1.) CH₂Cl₂, room temperature, 2.5 h, 2.) CH₂Cl₂, room temperature, 16 h

3: 91 percent / sodium methoxide / methanol / 0.5 h / Ambient temperature

With pyridine; sodium methylate; sodium hydrogencarbonate; In methanol; dichloromethane;

DOI:10.1080/10426509608046350

Reference yield:

dimethyl {3-[(tert-butoxycarbonyl)(tert-butoxycarbonyloxy)amino]-1-cyclohexen-1-yl}phosphonate (180294-88-6) → dimethyl {[3-(N-acetyl-N-acetyloxy)amino]-1-cyclohexen-1-yl}phosphonate (180294-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 6 h / Ambient temperature

2: 1.) NaHCO₃, 2.) pyridine / 1.) CH₂Cl₂, room temperature, 2.5 h, 2.) CH₂Cl₂, room temperature, 16 h

With pyridine; sodium hydrogencarbonate; In dichloromethane;

DOI:10.1080/10426509608046350

upstream raw materials:

N,N-di(tert-butoxycarbonyl)hydroxylamine

(3-hydroxy-1-cyclohexenyl)phosphonsaeure-dimethylester

Downstream raw materials:

dimethyl {[3-(N-acetyl-N-acetyloxy)amino]-1-cyclohexen-1-yl}phosphonate