(-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14α,17α-diyl bis-N-mesyl-(S)-phenylalaninate

Base Information

Chemical Name:(-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14α,17α-diyl bis-N-mesyl-(S)-phenylalaninate
CAS No.:69661-05-8
Molecular Formula:C₃₉H₄₈N₂O₉S₂
Molecular Weight:752.95
Hs Code.:

Synonyms:(-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14α,17α-diyl bis-N-mesyl-(S)-phenylalaninate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14α,17α-diyl bis-N-mesyl-(S)-phenylalaninate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14α,17α-diyl bis-N-mesyl-(S)-phenylalaninate

There total 5 articles about (-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14α,17α-diyl bis-N-mesyl-(S)-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 85760-98-1
3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14α,17α-diol

: 63640-54-0
(+)-N-mesyl-(S)-phenylalanyl chloride

: 69661-05-8
(-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14α,17α-diyl bis-N-mesyl-(S)-phenylalaninate

: 69661-06-9,69686-37-9
(+)-3-methoxy-17α-hydroxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14α-yl N-mesyl-(S)-phenylalaninate

: 69661-06-9,69686-37-9
(-)-3-methoxy-14α-hydroxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-17α-yl N-mesyl-(S)-phenylalaninate

Guidance literature:: With pyridine; In tetrahydrofuran; at 0 ℃; for 4h; Yields of byproduct given;
DOI:10.1016/0040-4020(80)80161-X

Reference yield:

: 25221-98-1
2-[(2E)-2-(6-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene)-ethyl]-2-methylcyclopentane-1,3-dione

: 69661-05-8
(-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14α,17α-diyl bis-N-mesyl-(S)-phenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium tri-t-butoxyaluminum hydride, 2.) LAH / 1.)2.) THF, (-68)-(-72) deg C, 1 h

2: 23 percent / pyridine / tetrahydrofuran / Ambient temperature

With pyridine; lithium aluminium tetrahydride; lithium tri(t-butoxy)aluminum hydride; In tetrahydrofuran;
DOI:10.1016/0040-4020(80)80161-X

Reference yield:

: 6563-81-1,6563-82-2,16215-41-1,16976-26-4,16976-39-9,51773-46-7
dl-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-17α-ol-14-one

: 69661-05-8
(-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14α,17α-diyl bis-N-mesyl-(S)-phenylalaninate

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / pyridine

2: 1.) NaBH₄ / 1.) MeOH

3: 23 percent / pyridine / tetrahydrofuran / Ambient temperature

With pyridine; sodium tetrahydroborate; In tetrahydrofuran;
DOI:10.1016/0040-4020(80)80161-X