63640-54-0

Usage

Uses

Used in Pharmaceutical Industry:
(+)-(s)-n-Methylsulfonylphenylalanyl chloride is used as a selective inhibitor of angiotensin-converting enzyme (ACE) for the potential treatment of cardiovascular diseases. Its ability to inhibit ACE makes it a promising candidate for the development of new drugs targeting cardiovascular conditions.
Used in Medicinal Research:
(+)-(s)-n-Methylsulfonylphenylalanyl chloride is used as a valuable tool in drug discovery and development due to its unique structure and properties. It aids researchers in the synthesis of various peptides and drug molecules, contributing to the advancement of new therapeutic agents.
Used in Biochemistry:
(+)-(s)-n-Methylsulfonylphenylalanyl chloride is utilized in the study of biological activity and potential therapeutic applications, making it an important chemical compound in the field of biochemistry. Its role in understanding the mechanisms of action and interactions with biological systems is crucial for the development of novel treatments and therapies.

Upstream product

• 63-91-2 L-phenylalanine 
• 124-63-0 methanesulfonyl chloride 
• 42361-65-9 N-(methylsulfonyl)-L-phenylalanine 

Downstream Products

• 63603-18-9 (+)-4(S)-hydroxy-2-cyclopenten-1(R)-yl N-mesyl-(S)-phenylalaninate 
• 63603-17-8 (-)-2-cyclopenten-1(R),4(S)-diyl bis-N-mesyl-(S)-phenylalaninate 
• 63603-18-9 (-)-4(R)-hydroxy-2-cyclopenten-1(S)-yl N-mesyl-(S)-phenylalaninate 
• 89784-51-0 7-(N-mesyl-L-phenylalanyl)amino-4-nitrobenzo-2-oxa-1,3-diazole 
• 67499-73-4 (+)-4(S)-tetrahydropyranoxy-2-cyclopenten-1(R)-yl N-mesyl-(S)-phenylalaninate 
• 67499-73-4 (-)-4(R)-tetrahydropyranoxy-2-cyclopenten-1(S)-yl N-mesyl-(S)-phenylalaninate 
• 69661-05-8 (-)-3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14α,17α-diyl bis-N-mesyl-(S)-phenylalaninate 
• 69661-06-9 (+)-3-methoxy-17α-hydroxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-14α-yl N-mesyl-(S)-phenylalaninate 
• 69661-06-9 (-)-3-methoxy-14α-hydroxy-8(14)-seco-1,3,5(10),9(11)-estratetraen-17α-yl N-mesyl-(S)-phenylalaninate 
• 127978-20-5 2-Allyl-6-methoxyphenyl N-mesyl-L-phenylalanylate 

Relevant academic research and scientific papers

STEREOCHEMICAL STUDIES - LVII. SYNTHESIS OF OPTICALLY ACTIVE COMPOUNDS BY THE NOVEL USE OF MESO-COMPOUNDS -1. EFFICIENT SYNTHESIS OF TWO STRUCTURAL TYPES OF OPTICALLY PURE PROSTAGLANDIN INTERMEDIATES.

With an aim to overcome several inefficient aspects of ordinary methods of preparing optically active compounds, we have developed a new method which recommends utilization of symmetrically functionalized meso-compounds in place of racemic compounds.As shown in Scheme 1, when the meso-compound (I) is monofunctionalized by an optically active functional group (A) and each of the formed diastereomers (II and III) is subjected to further chemical elaborations including protective group transposition, it is theoretically possible to convert the total amount of the starting material (I) into the requisite optically pure product (VI or VII) by selecting synthetic schemes.By employing this novel concept, two structural types of the prostaglandin intermediates ((-)- and (+)-2a,b) have been prepared from the meso-diols (1a,b) by way of the two diastereomeric monoesters (13a,b and 14a,b) which are produced by the reactions 1a,b with N-mesyl- and N-phthaloyl-(S)-phenylalanyl chloride (3a,b).