(-)-(1R,5S)-1-(acetoxymethyl)-3-benzyl-5-hydroxymethyl-9-methylene-3-azabicyclo<3.3.1>nonane

Base Information

Chemical Name:(-)-(1R,5S)-1-(acetoxymethyl)-3-benzyl-5-hydroxymethyl-9-methylene-3-azabicyclo<3.3.1>nonane
CAS No.:124097-07-0
Molecular Formula:C₂₀H₂₇NO₃
Molecular Weight:329.439
Hs Code.:

Synonyms:(-)-(1R,5S)-1-(acetoxymethyl)-3-benzyl-5-hydroxymethyl-9-methylene-3-azabicyclo<3.3.1>nonane

Suppliers and Price of (-)-(1R,5S)-1-(acetoxymethyl)-3-benzyl-5-hydroxymethyl-9-methylene-3-azabicyclo<3.3.1>nonane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-(1R,5S)-1-(acetoxymethyl)-3-benzyl-5-hydroxymethyl-9-methylene-3-azabicyclo<3.3.1>nonane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-(1R,5S)-1-(acetoxymethyl)-3-benzyl-5-hydroxymethyl-9-methylene-3-azabicyclo<3.3.1>nonane

There total 6 articles about (-)-(1R,5S)-1-(acetoxymethyl)-3-benzyl-5-hydroxymethyl-9-methylene-3-azabicyclo<3.3.1>nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.8%

: 108-05-4,9003-20-7
vinyl acetate

: 113161-31-2
3-benzyl-1,5-(dihydroxymethyl)-9-methylene-3-azabicyclo<3.3.1>nonane

: 124022-28-2
1,5-(diacetoxymethyl)-3-benzyl-9-methylene-3-azabicyclo<3.3.1>nonane

: 124097-07-0
(-)-(1R,5S)-1-(acetoxymethyl)-3-benzyl-5-hydroxymethyl-9-methylene-3-azabicyclo<3.3.1>nonane

Guidance literature:: for 16h; Ambient temperature; Candida cylindcacea lipase;
DOI:10.1016/0957-4166(95)00267-S

Reference yield: 4.0%

: 124022-28-2
1,5-(diacetoxymethyl)-3-benzyl-9-methylene-3-azabicyclo<3.3.1>nonane

: 113161-31-2
3-benzyl-1,5-(dihydroxymethyl)-9-methylene-3-azabicyclo<3.3.1>nonane

: 124022-29-3
Acetic acid (1S,5R)-3-benzyl-5-hydroxymethyl-9-methylene-3-aza-bicyclo[3.3.1]non-1-ylmethyl ester

: 124097-07-0
(-)-(1R,5S)-1-(acetoxymethyl)-3-benzyl-5-hydroxymethyl-9-methylene-3-azabicyclo<3.3.1>nonane

Guidance literature:: With Candida cylindracea lipase-type VII; Celite; In 2,2,4-trimethylpentane; water; at 35 ℃; for 48h; Yield given. Title compound not separated from byproducts;
DOI:10.1021/ja00159a042

Reference yield:

: 113161-22-1
dimethyl 3-benzyl-9-methylene-3-azabicyclo<3.3.1>nonane-1,5-dicarboxylate

: 124097-07-0
(-)-(1R,5S)-1-(acetoxymethyl)-3-benzyl-5-hydroxymethyl-9-methylene-3-azabicyclo<3.3.1>nonane

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Ambient temperature

2: 1 percent / Candidia cylindracea lipase-type VII / benzene / 11 h / 28 °C

3: Celite, Candida cylindracea lipase-type VII / 2,2,4-trimethyl-pentane; H₂O / 48 h / 35 °C

With lithium aluminium tetrahydride; Candida cylindracea lipase-type VII; Candidia cylindracea lipase-type VII; Celite; In tetrahydrofuran; 2,2,4-trimethylpentane; water; benzene;
DOI:10.1021/ja00159a042